Primary cilia: The central role in the electromagnetic field induced bone healing
Primary cilia have emerged as the cellular “antenna” that can receive and transduce extracellular chemical/physical signals, thus playing an important role in regulating cellular activities. Although the electromagnetic field (EMF) is an effective treatment for bone fractures since 1978, however, th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1062119/full |
| _version_ | 1797987059377373184 |
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| author | Yangmengfan Chen Chao Lu Xifu Shang Kerong Wu Kun Chen |
| author_facet | Yangmengfan Chen Chao Lu Xifu Shang Kerong Wu Kun Chen |
| author_sort | Yangmengfan Chen |
| collection | DOAJ |
| description | Primary cilia have emerged as the cellular “antenna” that can receive and transduce extracellular chemical/physical signals, thus playing an important role in regulating cellular activities. Although the electromagnetic field (EMF) is an effective treatment for bone fractures since 1978, however, the detailed mechanisms leading to such positive effects are still unclear. Primary cilia may play a central role in receiving EMF signals, translating physical signals into biochemical information, and initiating various signalingsignaling pathways to transduce signals into the nucleus. In this review, we elucidated the process of bone healing, the structure, and function of primary cilia, as well as the application and mechanism of EMF in treating fracture healing. To comprehensively understand the process of bone healing, we used bioinformatics to analyze the molecular change and associated the results with other studies. Moreover, this review summarizedsummarized some limitations in EMFs-related research and provides an outlook for ongoing studies. In conclusion, this review illustrated the primary cilia and related molecular mechanisms in the EMF-induced bone healing process, and it may shed light on future research. |
| first_indexed | 2024-04-11T07:41:50Z |
| format | Article |
| id | doaj.art-7d376e325ea74d60ba0592674e414a09 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T07:41:50Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7d376e325ea74d60ba0592674e414a092022-12-22T04:36:29ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.10621191062119Primary cilia: The central role in the electromagnetic field induced bone healingYangmengfan Chen0Chao Lu1Xifu Shang2Kerong Wu3Kun Chen4Department of Orthopedics, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Hand and Foot Surgery, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaPrimary cilia have emerged as the cellular “antenna” that can receive and transduce extracellular chemical/physical signals, thus playing an important role in regulating cellular activities. Although the electromagnetic field (EMF) is an effective treatment for bone fractures since 1978, however, the detailed mechanisms leading to such positive effects are still unclear. Primary cilia may play a central role in receiving EMF signals, translating physical signals into biochemical information, and initiating various signalingsignaling pathways to transduce signals into the nucleus. In this review, we elucidated the process of bone healing, the structure, and function of primary cilia, as well as the application and mechanism of EMF in treating fracture healing. To comprehensively understand the process of bone healing, we used bioinformatics to analyze the molecular change and associated the results with other studies. Moreover, this review summarizedsummarized some limitations in EMFs-related research and provides an outlook for ongoing studies. In conclusion, this review illustrated the primary cilia and related molecular mechanisms in the EMF-induced bone healing process, and it may shed light on future research.https://www.frontiersin.org/articles/10.3389/fphar.2022.1062119/fullelectromagnetic fieldsprimary ciliaosteogenesissignaling pathwaybone |
| spellingShingle | Yangmengfan Chen Chao Lu Xifu Shang Kerong Wu Kun Chen Primary cilia: The central role in the electromagnetic field induced bone healing Frontiers in Pharmacology electromagnetic fields primary cilia osteogenesis signaling pathway bone |
| title | Primary cilia: The central role in the electromagnetic field induced bone healing |
| title_full | Primary cilia: The central role in the electromagnetic field induced bone healing |
| title_fullStr | Primary cilia: The central role in the electromagnetic field induced bone healing |
| title_full_unstemmed | Primary cilia: The central role in the electromagnetic field induced bone healing |
| title_short | Primary cilia: The central role in the electromagnetic field induced bone healing |
| title_sort | primary cilia the central role in the electromagnetic field induced bone healing |
| topic | electromagnetic fields primary cilia osteogenesis signaling pathway bone |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1062119/full |
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