Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based Therapy
The skin represents the exterior interface between the human body with the environment while providing a home to trillions of the commensal microorganisms—collectively referred to as the skin microbiota. These microbes that coexist in an established balance play a pivotal role in the protection of c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2020.570261/full |
| _version_ | 1818315824451026944 |
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| author | Hong Zhou Linlin Shi Yuanyuan Ren Xi Tan Wei Liu Wei Liu Zhi Liu Zhi Liu |
| author_facet | Hong Zhou Linlin Shi Yuanyuan Ren Xi Tan Wei Liu Wei Liu Zhi Liu Zhi Liu |
| author_sort | Hong Zhou |
| collection | DOAJ |
| description | The skin represents the exterior interface between the human body with the environment while providing a home to trillions of the commensal microorganisms—collectively referred to as the skin microbiota. These microbes that coexist in an established balance play a pivotal role in the protection of cutaneous health and the orchestration of skin homeostasis. However, the well-controlled but delicate balance can be perturbed by alterations in the skin microbial communities, namely, dysbiosis, often due to commensals defeated by pathogens competing for space and nutrients, which leads to the occurrence of multiple cutaneous disorders. In view of this, the analysis of skin microbiota constituents in skin diseases is crucial for defining the role of commensal microbes and treatment of skin diseases. Emerging evidence shows that the ecology-based therapy of microbial transplantation has been proven as a valid therapeutic strategy for cutaneous disorders caused by skin microbial dysbiosis. Although its mechanism is not well-understood, there are already some applications for ecology-based therapy with the aim of correcting the imbalances on the cutaneous ecosystem. In this review, we summarize the interactions between dysbiosis and the cutaneous disorders, including homeostasis and dysbiosis of skin microbiota, microbial composition in skin diseases, and the mechanisms and applications of reversing or ameliorating the dysbiosis by the targeted manipulation of the skin microbiota, which may contribute to aid development of therapeutic modality for ecology-based therapy. |
| first_indexed | 2024-12-13T09:11:40Z |
| format | Article |
| id | doaj.art-7d3d96d7a256475ab20d17a67275c284 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-13T09:11:40Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-7d3d96d7a256475ab20d17a67275c2842022-12-21T23:52:56ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-10-011010.3389/fcimb.2020.570261570261Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based TherapyHong Zhou0Linlin Shi1Yuanyuan Ren2Xi Tan3Wei Liu4Wei Liu5Zhi Liu6Zhi Liu7College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaNational Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan, ChinaCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaNational Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan, ChinaThe skin represents the exterior interface between the human body with the environment while providing a home to trillions of the commensal microorganisms—collectively referred to as the skin microbiota. These microbes that coexist in an established balance play a pivotal role in the protection of cutaneous health and the orchestration of skin homeostasis. However, the well-controlled but delicate balance can be perturbed by alterations in the skin microbial communities, namely, dysbiosis, often due to commensals defeated by pathogens competing for space and nutrients, which leads to the occurrence of multiple cutaneous disorders. In view of this, the analysis of skin microbiota constituents in skin diseases is crucial for defining the role of commensal microbes and treatment of skin diseases. Emerging evidence shows that the ecology-based therapy of microbial transplantation has been proven as a valid therapeutic strategy for cutaneous disorders caused by skin microbial dysbiosis. Although its mechanism is not well-understood, there are already some applications for ecology-based therapy with the aim of correcting the imbalances on the cutaneous ecosystem. In this review, we summarize the interactions between dysbiosis and the cutaneous disorders, including homeostasis and dysbiosis of skin microbiota, microbial composition in skin diseases, and the mechanisms and applications of reversing or ameliorating the dysbiosis by the targeted manipulation of the skin microbiota, which may contribute to aid development of therapeutic modality for ecology-based therapy.https://www.frontiersin.org/articles/10.3389/fcimb.2020.570261/fullhuman skin microbiotacutaneous disordersdysbiosisecology-based therapyapplications |
| spellingShingle | Hong Zhou Linlin Shi Yuanyuan Ren Xi Tan Wei Liu Wei Liu Zhi Liu Zhi Liu Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based Therapy Frontiers in Cellular and Infection Microbiology human skin microbiota cutaneous disorders dysbiosis ecology-based therapy applications |
| title | Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based Therapy |
| title_full | Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based Therapy |
| title_fullStr | Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based Therapy |
| title_full_unstemmed | Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based Therapy |
| title_short | Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based Therapy |
| title_sort | applications of human skin microbiota in the cutaneous disorders for ecology based therapy |
| topic | human skin microbiota cutaneous disorders dysbiosis ecology-based therapy applications |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2020.570261/full |
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