Brain Temperature and Its Fundamental Properties: A Review for Clinical Neuroscientists
Brain temperature, as an independent therapeutic target variable, has received increasingly intense clinical attention. To date, brain hypothermia represents the most potent neuroprotectant in laboratory studies. Although the impact of brain temperature is prevalent in a number of common human dise...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00307/full |
| _version_ | 1818272453850300416 |
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| author | Huan (John) eWang bonnie ewang kieran enormoyle kevin eJackson kevin espitler Matthew Field Sharrock claire emiller Catherine ebest Daniel eLlano Rose eDu |
| author_facet | Huan (John) eWang bonnie ewang kieran enormoyle kevin eJackson kevin espitler Matthew Field Sharrock claire emiller Catherine ebest Daniel eLlano Rose eDu |
| author_sort | Huan (John) eWang |
| collection | DOAJ |
| description | Brain temperature, as an independent therapeutic target variable, has received increasingly intense clinical attention. To date, brain hypothermia represents the most potent neuroprotectant in laboratory studies. Although the impact of brain temperature is prevalent in a number of common human diseases including: head trauma, stroke, multiple sclerosis, epilepsy, mood disorders, headaches, and neurodegenerative disorders, it is evident and well recognized that the therapeutic application of induced hypothermia is limited to a few highly selected clinical conditions such as cardiac arrest and hypoxic ischemic neonatal encephalopathy. Efforts to understand the fundamental aspects of brain temperature regulation are therefore critical for the development of safe, effective, and pragmatic clinical treatments for patients with brain injuries. Although centrally-mediated mechanisms to maintain a stable body temperature are relatively well established, very little is clinically known about brain temperature’s spatial and temporal distribution, its physiological and pathological fluctuations, and the mechanism underlying brain thermal homeostasis. The human brain, a metabolically expensive organ with intense heat production, is sensitive to fluctuations in temperature with regards to its functional activity and energy efficiency. In this review, we discuss several critical aspects concerning the fundamental properties of brain temperature from a clinical perspective. |
| first_indexed | 2024-12-12T21:42:19Z |
| format | Article |
| id | doaj.art-7d41314d23c5493c840d0dce441b4d1d |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T21:42:19Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-7d41314d23c5493c840d0dce441b4d1d2022-12-22T00:11:00ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2014-10-01810.3389/fnins.2014.0030788894Brain Temperature and Its Fundamental Properties: A Review for Clinical NeuroscientistsHuan (John) eWang0bonnie ewang1kieran enormoyle2kevin eJackson3kevin espitler4Matthew Field Sharrock5claire emiller6Catherine ebest7Daniel eLlano8Rose eDu9Carle foundation hospitalCarle Foundation Hospitaluniversity of illinoisUniversity of IllinoisCarle Foundation HospitalCarle foundation hospitaluniversity of illinoisUniversity of IllinoisUniversity of IllinoisBrigham and Women's Hospital- Harvard Medical SchoolBrain temperature, as an independent therapeutic target variable, has received increasingly intense clinical attention. To date, brain hypothermia represents the most potent neuroprotectant in laboratory studies. Although the impact of brain temperature is prevalent in a number of common human diseases including: head trauma, stroke, multiple sclerosis, epilepsy, mood disorders, headaches, and neurodegenerative disorders, it is evident and well recognized that the therapeutic application of induced hypothermia is limited to a few highly selected clinical conditions such as cardiac arrest and hypoxic ischemic neonatal encephalopathy. Efforts to understand the fundamental aspects of brain temperature regulation are therefore critical for the development of safe, effective, and pragmatic clinical treatments for patients with brain injuries. Although centrally-mediated mechanisms to maintain a stable body temperature are relatively well established, very little is clinically known about brain temperature’s spatial and temporal distribution, its physiological and pathological fluctuations, and the mechanism underlying brain thermal homeostasis. The human brain, a metabolically expensive organ with intense heat production, is sensitive to fluctuations in temperature with regards to its functional activity and energy efficiency. In this review, we discuss several critical aspects concerning the fundamental properties of brain temperature from a clinical perspective.http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00307/fullBrainCentral Nervous Systemcerebral blood flowtemperatureThermal Regulation |
| spellingShingle | Huan (John) eWang bonnie ewang kieran enormoyle kevin eJackson kevin espitler Matthew Field Sharrock claire emiller Catherine ebest Daniel eLlano Rose eDu Brain Temperature and Its Fundamental Properties: A Review for Clinical Neuroscientists Frontiers in Neuroscience Brain Central Nervous System cerebral blood flow temperature Thermal Regulation |
| title | Brain Temperature and Its Fundamental Properties: A Review for Clinical Neuroscientists |
| title_full | Brain Temperature and Its Fundamental Properties: A Review for Clinical Neuroscientists |
| title_fullStr | Brain Temperature and Its Fundamental Properties: A Review for Clinical Neuroscientists |
| title_full_unstemmed | Brain Temperature and Its Fundamental Properties: A Review for Clinical Neuroscientists |
| title_short | Brain Temperature and Its Fundamental Properties: A Review for Clinical Neuroscientists |
| title_sort | brain temperature and its fundamental properties a review for clinical neuroscientists |
| topic | Brain Central Nervous System cerebral blood flow temperature Thermal Regulation |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00307/full |
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