Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma
We discuss a single case of Hemophagocytic lymphohistiocytosis (HLH) due to NK-type non-Hodgkin lymphoma and Epstein-Barr virus reactivation with multiorgan dysfunction and distributive shock in which we performed cytokine hemoadsorption with Cytosorb ®. A full microbiological panel was carried out,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.925751/full |
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| author | Juan Carlos Ruiz-Rodríguez Juan Carlos Ruiz-Rodríguez Juan Carlos Ruiz-Rodríguez Luis Chiscano-Camón Luis Chiscano-Camón Luis Chiscano-Camón Adolf Ruiz-Sanmartin Adolf Ruiz-Sanmartin Adolf Ruiz-Sanmartin Clara Palmada Clara Palmada Ivan Bajaña Ivan Bajaña Gloria Iacoboni Gloria Iacoboni Camilo Bonilla Camilo Bonilla Alejandra García-Roche Alejandra García-Roche Erika Paola Plata-Menchaca Erika Paola Plata-Menchaca Erika Paola Plata-Menchaca Carolina Maldonado Carolina Maldonado Marcos Pérez-Carrasco Marcos Pérez-Carrasco Marcos Pérez-Carrasco Mónica Martinez-Gallo Mónica Martinez-Gallo Mónica Martinez-Gallo Mónica Martinez-Gallo Clara Franco-Jarava Clara Franco-Jarava Manuel Hernández-González Manuel Hernández-González Manuel Hernández-González Ricard Ferrer Ricard Ferrer Ricard Ferrer |
| author_facet | Juan Carlos Ruiz-Rodríguez Juan Carlos Ruiz-Rodríguez Juan Carlos Ruiz-Rodríguez Luis Chiscano-Camón Luis Chiscano-Camón Luis Chiscano-Camón Adolf Ruiz-Sanmartin Adolf Ruiz-Sanmartin Adolf Ruiz-Sanmartin Clara Palmada Clara Palmada Ivan Bajaña Ivan Bajaña Gloria Iacoboni Gloria Iacoboni Camilo Bonilla Camilo Bonilla Alejandra García-Roche Alejandra García-Roche Erika Paola Plata-Menchaca Erika Paola Plata-Menchaca Erika Paola Plata-Menchaca Carolina Maldonado Carolina Maldonado Marcos Pérez-Carrasco Marcos Pérez-Carrasco Marcos Pérez-Carrasco Mónica Martinez-Gallo Mónica Martinez-Gallo Mónica Martinez-Gallo Mónica Martinez-Gallo Clara Franco-Jarava Clara Franco-Jarava Manuel Hernández-González Manuel Hernández-González Manuel Hernández-González Ricard Ferrer Ricard Ferrer Ricard Ferrer |
| author_sort | Juan Carlos Ruiz-Rodríguez |
| collection | DOAJ |
| description | We discuss a single case of Hemophagocytic lymphohistiocytosis (HLH) due to NK-type non-Hodgkin lymphoma and Epstein-Barr virus reactivation with multiorgan dysfunction and distributive shock in which we performed cytokine hemoadsorption with Cytosorb ®. A full microbiological panel was carried out, including screening for imported disease, standard serologies and cultures for bacterial and fungal infection. A liver biopsy and bone marrow aspirate were performed, confirming the diagnosis. The patients fulfilled the HLH-2004 diagnostic criteria, and according to the 2018 Consensus Statements by the HLH Steering Committee of the Histiocyte Society, dexamethasone and etoposide were started. There was an associated hypercytokinemia and, due to refractory distributive shock, rescue therapy with cytokine hemoadsorption was performed during 24 h (within day 2 and 3 from ICU admission). After starting this procedure, rapid hemodynamic control was achieved with a significant reduction in vasopressor support requirements. This case report highlights that cytokine hemoadsorption can be an effective since rapid decrease in IL-10 levels and a significant hemodynamic improvement was achieved. |
| first_indexed | 2024-04-11T22:35:01Z |
| format | Article |
| id | doaj.art-7d41484ebd32486ba8763032f3562af3 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T22:35:01Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-7d41484ebd32486ba8763032f3562af32022-12-22T03:59:15ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.925751925751Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphomaJuan Carlos Ruiz-Rodríguez0Juan Carlos Ruiz-Rodríguez1Juan Carlos Ruiz-Rodríguez2Luis Chiscano-Camón3Luis Chiscano-Camón4Luis Chiscano-Camón5Adolf Ruiz-Sanmartin6Adolf Ruiz-Sanmartin7Adolf Ruiz-Sanmartin8Clara Palmada9Clara Palmada10Ivan Bajaña11Ivan Bajaña12Gloria Iacoboni13Gloria Iacoboni14Camilo Bonilla15Camilo Bonilla16Alejandra García-Roche17Alejandra García-Roche18Erika Paola Plata-Menchaca19Erika Paola Plata-Menchaca20Erika Paola Plata-Menchaca21Carolina Maldonado22Carolina Maldonado23Marcos Pérez-Carrasco24Marcos Pérez-Carrasco25Marcos Pérez-Carrasco26Mónica Martinez-Gallo27Mónica Martinez-Gallo28Mónica Martinez-Gallo29Mónica Martinez-Gallo30Clara Franco-Jarava31Clara Franco-Jarava32Manuel Hernández-González33Manuel Hernández-González34Manuel Hernández-González35Ricard Ferrer36Ricard Ferrer37Ricard Ferrer38Intensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainDepartament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, SpainIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainDepartament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, SpainIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainDepartament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, SpainIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainDepartament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, SpainHematology Department, Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainDepartament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, SpainIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainDepartament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, SpainDepartament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, SpainImmunology Division, Vall d'Hebron University Hospital, Barcelona, SpainDiagnostic Immunology Research Group, Vall d'Hebron Research Institute, Barcelona, SpainDepartment of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona (UAB), Barcelona, SpainImmunology Division, Vall d'Hebron University Hospital, Barcelona, SpainDiagnostic Immunology Research Group, Vall d'Hebron Research Institute, Barcelona, SpainImmunology Division, Vall d'Hebron University Hospital, Barcelona, SpainDiagnostic Immunology Research Group, Vall d'Hebron Research Institute, Barcelona, SpainDepartment of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona (UAB), Barcelona, SpainIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainShock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, SpainDepartament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, SpainWe discuss a single case of Hemophagocytic lymphohistiocytosis (HLH) due to NK-type non-Hodgkin lymphoma and Epstein-Barr virus reactivation with multiorgan dysfunction and distributive shock in which we performed cytokine hemoadsorption with Cytosorb ®. A full microbiological panel was carried out, including screening for imported disease, standard serologies and cultures for bacterial and fungal infection. A liver biopsy and bone marrow aspirate were performed, confirming the diagnosis. The patients fulfilled the HLH-2004 diagnostic criteria, and according to the 2018 Consensus Statements by the HLH Steering Committee of the Histiocyte Society, dexamethasone and etoposide were started. There was an associated hypercytokinemia and, due to refractory distributive shock, rescue therapy with cytokine hemoadsorption was performed during 24 h (within day 2 and 3 from ICU admission). After starting this procedure, rapid hemodynamic control was achieved with a significant reduction in vasopressor support requirements. This case report highlights that cytokine hemoadsorption can be an effective since rapid decrease in IL-10 levels and a significant hemodynamic improvement was achieved.https://www.frontiersin.org/articles/10.3389/fmed.2022.925751/fullhemophagocytic lymphohistiocytosiscytokine stormmultiorgan dysfunctioncytokine hemoadsorptionshock |
| spellingShingle | Juan Carlos Ruiz-Rodríguez Juan Carlos Ruiz-Rodríguez Juan Carlos Ruiz-Rodríguez Luis Chiscano-Camón Luis Chiscano-Camón Luis Chiscano-Camón Adolf Ruiz-Sanmartin Adolf Ruiz-Sanmartin Adolf Ruiz-Sanmartin Clara Palmada Clara Palmada Ivan Bajaña Ivan Bajaña Gloria Iacoboni Gloria Iacoboni Camilo Bonilla Camilo Bonilla Alejandra García-Roche Alejandra García-Roche Erika Paola Plata-Menchaca Erika Paola Plata-Menchaca Erika Paola Plata-Menchaca Carolina Maldonado Carolina Maldonado Marcos Pérez-Carrasco Marcos Pérez-Carrasco Marcos Pérez-Carrasco Mónica Martinez-Gallo Mónica Martinez-Gallo Mónica Martinez-Gallo Mónica Martinez-Gallo Clara Franco-Jarava Clara Franco-Jarava Manuel Hernández-González Manuel Hernández-González Manuel Hernández-González Ricard Ferrer Ricard Ferrer Ricard Ferrer Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma Frontiers in Medicine hemophagocytic lymphohistiocytosis cytokine storm multiorgan dysfunction cytokine hemoadsorption shock |
| title | Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma |
| title_full | Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma |
| title_fullStr | Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma |
| title_full_unstemmed | Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma |
| title_short | Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma |
| title_sort | case report cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal nk t cell lymphoma |
| topic | hemophagocytic lymphohistiocytosis cytokine storm multiorgan dysfunction cytokine hemoadsorption shock |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.925751/full |
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