Research advances in mechanism of melanosomes transport and regulation in melanocytes
Melanosome (MS) is a special membrane organelle which synthesizes, stores and transports melanin in melanocytes (MC). The diversity of human skin color lies on the type, quantity, distribution and maturation of MS. The transport of MS in MC is the result of the interaction between three kinesins and...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2022-10-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-10-1581.pdf |
| _version_ | 1797365863351844864 |
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| author | NING Jing, ZHANG Ru-zhi |
| author_facet | NING Jing, ZHANG Ru-zhi |
| author_sort | NING Jing, ZHANG Ru-zhi |
| collection | DOAJ |
| description | Melanosome (MS) is a special membrane organelle which synthesizes, stores and transports melanin in melanocytes (MC). The diversity of human skin color lies on the type, quantity, distribution and maturation of MS. The transport of MS in MC is the result of the interaction between three kinesins and two kinds of cytoskeletons, which are affected by many regulatory factors. A variety of pigmented diseases are strongly associated with MS transport malfunction. A deeper understanding of the mechanism for MS transport may improve the cognition of MS transport-related diseases and potentially provide a novel strategy for clinical treatment and pharmaceutical development. |
| first_indexed | 2024-03-08T16:55:00Z |
| format | Article |
| id | doaj.art-7d41fcfd091842f6b23da1eab2b5247b |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:55:00Z |
| publishDate | 2022-10-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-7d41fcfd091842f6b23da1eab2b5247b2024-01-05T02:36:29ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252022-10-0142101581158410.16352/j.issn.1001-6325.2022.10.1581Research advances in mechanism of melanosomes transport and regulation in melanocytesNING Jing, ZHANG Ru-zhi0Department of Dermatology, the Third Affiliated Hospital of Soochow University, Changzhou 213003, ChinaMelanosome (MS) is a special membrane organelle which synthesizes, stores and transports melanin in melanocytes (MC). The diversity of human skin color lies on the type, quantity, distribution and maturation of MS. The transport of MS in MC is the result of the interaction between three kinesins and two kinds of cytoskeletons, which are affected by many regulatory factors. A variety of pigmented diseases are strongly associated with MS transport malfunction. A deeper understanding of the mechanism for MS transport may improve the cognition of MS transport-related diseases and potentially provide a novel strategy for clinical treatment and pharmaceutical development.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-10-1581.pdfmelanosome transport|microtubules|actin filaments|kinesin|myosin-va |
| spellingShingle | NING Jing, ZHANG Ru-zhi Research advances in mechanism of melanosomes transport and regulation in melanocytes Jichu yixue yu linchuang melanosome transport|microtubules|actin filaments|kinesin|myosin-va |
| title | Research advances in mechanism of melanosomes transport and regulation in melanocytes |
| title_full | Research advances in mechanism of melanosomes transport and regulation in melanocytes |
| title_fullStr | Research advances in mechanism of melanosomes transport and regulation in melanocytes |
| title_full_unstemmed | Research advances in mechanism of melanosomes transport and regulation in melanocytes |
| title_short | Research advances in mechanism of melanosomes transport and regulation in melanocytes |
| title_sort | research advances in mechanism of melanosomes transport and regulation in melanocytes |
| topic | melanosome transport|microtubules|actin filaments|kinesin|myosin-va |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-10-1581.pdf |
| work_keys_str_mv | AT ningjingzhangruzhi researchadvancesinmechanismofmelanosomestransportandregulationinmelanocytes |