SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes

SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes

Abstract Background Facioscapulohumeral muscular dystrophy (FSHD) is in most cases caused by a contraction of the D4Z4 macrosatellite repeat on chromosome 4 (FSHD1) or by mutations in the SMCHD1 or DNMT3B gene (FSHD2). Both situations result in the incomplete epigenetic repression of the D4Z4-encode...

Full description

Bibliographic Details
Main Authors: Amanda G. Mason, Roderick C. Slieker, Judit Balog, Richard J. L. F. Lemmers, Chao-Jen Wong, Zizhen Yao, Jong-Won Lim, Galina N. Filippova, Enrico Ne, Rabi Tawil, Bas T. Heijmans, Stephen J. Tapscott, Silvère M. van der Maarel
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Skeletal Muscle
Subjects:
SMCHD1
FSHD
Chromatin
Methylation
Online Access:http://link.springer.com/article/10.1186/s13395-017-0129-7

Similar Items

Similar Items