Plant Natural Sources of the Endocannabinoid (<i>E</i>)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature
(E)-β-caryophyllene (BCP) is a natural sesquiterpene hydrocarbon present in hundreds of plant species. BCP possesses several important pharmacological activities, ranging from pain treatment to neurological and metabolic disorders. These are mainly due to its ability to interact with the cannabinoid...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/18/6540 |
| _version_ | 1797554348970999808 |
|---|---|
| author | Massimo E. Maffei |
| author_facet | Massimo E. Maffei |
| author_sort | Massimo E. Maffei |
| collection | DOAJ |
| description | (E)-β-caryophyllene (BCP) is a natural sesquiterpene hydrocarbon present in hundreds of plant species. BCP possesses several important pharmacological activities, ranging from pain treatment to neurological and metabolic disorders. These are mainly due to its ability to interact with the cannabinoid receptor 2 (CB2) and the complete lack of interaction with the brain CB1. A systematic analysis of plant species with essential oils containing a BCP percentage > 10% provided almost 300 entries with species belonging to 51 families. The essential oils were found to be extracted from 13 plant parts and samples originated from 56 countries worldwide. Statistical analyses included the evaluation of variability in BCP% and yield% as well as the statistical linkage between families, plant parts and countries of origin by cluster analysis. Identified species were also grouped according to their presence in the Belfrit list. The survey evidences the importance of essential oil yield evaluation in support of the chemical analysis. The results provide a comprehensive picture of the species with the highest BCP and yield percentages. |
| first_indexed | 2024-03-10T16:30:46Z |
| format | Article |
| id | doaj.art-7d44bea18fcc4da9a2eb1cb4012b4262 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:30:46Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7d44bea18fcc4da9a2eb1cb4012b42622023-11-20T12:52:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012118654010.3390/ijms21186540Plant Natural Sources of the Endocannabinoid (<i>E</i>)-β-Caryophyllene: A Systematic Quantitative Analysis of Published LiteratureMassimo E. Maffei0Department of Life Sciences and Systems Biology, University of Turin, Via Quarello 15/a, 10135 Turin, Italy(E)-β-caryophyllene (BCP) is a natural sesquiterpene hydrocarbon present in hundreds of plant species. BCP possesses several important pharmacological activities, ranging from pain treatment to neurological and metabolic disorders. These are mainly due to its ability to interact with the cannabinoid receptor 2 (CB2) and the complete lack of interaction with the brain CB1. A systematic analysis of plant species with essential oils containing a BCP percentage > 10% provided almost 300 entries with species belonging to 51 families. The essential oils were found to be extracted from 13 plant parts and samples originated from 56 countries worldwide. Statistical analyses included the evaluation of variability in BCP% and yield% as well as the statistical linkage between families, plant parts and countries of origin by cluster analysis. Identified species were also grouped according to their presence in the Belfrit list. The survey evidences the importance of essential oil yield evaluation in support of the chemical analysis. The results provide a comprehensive picture of the species with the highest BCP and yield percentages.https://www.mdpi.com/1422-0067/21/18/6540plant speciesessential oilyieldpercentages of (E)-β-caryophylleneBelfrit listplant part |
| spellingShingle | Massimo E. Maffei Plant Natural Sources of the Endocannabinoid (<i>E</i>)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature International Journal of Molecular Sciences plant species essential oil yield percentages of (E)-β-caryophyllene Belfrit list plant part |
| title | Plant Natural Sources of the Endocannabinoid (<i>E</i>)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature |
| title_full | Plant Natural Sources of the Endocannabinoid (<i>E</i>)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature |
| title_fullStr | Plant Natural Sources of the Endocannabinoid (<i>E</i>)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature |
| title_full_unstemmed | Plant Natural Sources of the Endocannabinoid (<i>E</i>)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature |
| title_short | Plant Natural Sources of the Endocannabinoid (<i>E</i>)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature |
| title_sort | plant natural sources of the endocannabinoid i e i β caryophyllene a systematic quantitative analysis of published literature |
| topic | plant species essential oil yield percentages of (E)-β-caryophyllene Belfrit list plant part |
| url | https://www.mdpi.com/1422-0067/21/18/6540 |
| work_keys_str_mv | AT massimoemaffei plantnaturalsourcesoftheendocannabinoidieibcaryophylleneasystematicquantitativeanalysisofpublishedliterature |