Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery
Magnetically driven nanosponges with potential application as targeted drug delivery systems were prepared via the addition of magnetite nanoparticles to the synthesis of cyclodextrin and maltodextrin polymers crosslinked with 1,1′-carbonyldiimidazole. The magnetic nanoparticles were obtained separa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/5/754 |
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| author | Fabrizio Caldera Roberto Nisticò Giuliana Magnacca Adrián Matencio Yousef Khazaei Monfared Francesco Trotta |
| author_facet | Fabrizio Caldera Roberto Nisticò Giuliana Magnacca Adrián Matencio Yousef Khazaei Monfared Francesco Trotta |
| author_sort | Fabrizio Caldera |
| collection | DOAJ |
| description | Magnetically driven nanosponges with potential application as targeted drug delivery systems were prepared via the addition of magnetite nanoparticles to the synthesis of cyclodextrin and maltodextrin polymers crosslinked with 1,1′-carbonyldiimidazole. The magnetic nanoparticles were obtained separately via a coprecipitation mechanism involving inorganic iron salts in an alkaline environment. Four composite nanosponges were prepared by varying the content of magnetic nanoparticles (5 wt% and 10 wt%) in the cyclodextrin- and maltodextrin-based polymer matrix. The magnetic nanosponges were then characterised by FTIR, TGA, XRD, FESEM, and HRTEM analysis. The magnetic properties of the nanosponges were investigated via magnetisation curves collected at RT. Finally, the magnetic nanosponges were loaded with doxorubicin and tested as a drug delivery system. The nanosponges exhibited a loading capacity of approximately 3 wt%. Doxorubicin was released by the loaded nanosponges with sustained kinetics over a prolonged period of time. |
| first_indexed | 2024-03-09T20:28:16Z |
| format | Article |
| id | doaj.art-7d457182352a40889a1fb601066fd0bc |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T20:28:16Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-7d457182352a40889a1fb601066fd0bc2023-11-23T23:29:38ZengMDPI AGNanomaterials2079-49912022-02-0112575410.3390/nano12050754Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug DeliveryFabrizio Caldera0Roberto Nisticò1Giuliana Magnacca2Adrián Matencio3Yousef Khazaei Monfared4Francesco Trotta5Department of Chemistry, NIS Centre, University of Torino, Via P. Giuria 7, 10125 Torino, ItalyDepartment of Materials Science, University of Milano-Bicocca, Via R. Cozzi 55, 20125 Milano, ItalyDepartment of Chemistry, NIS Centre, University of Torino, Via P. Giuria 7, 10125 Torino, ItalyDepartment of Chemistry, NIS Centre, University of Torino, Via P. Giuria 7, 10125 Torino, ItalyDepartment of Chemistry, NIS Centre, University of Torino, Via P. Giuria 7, 10125 Torino, ItalyDepartment of Chemistry, NIS Centre, University of Torino, Via P. Giuria 7, 10125 Torino, ItalyMagnetically driven nanosponges with potential application as targeted drug delivery systems were prepared via the addition of magnetite nanoparticles to the synthesis of cyclodextrin and maltodextrin polymers crosslinked with 1,1′-carbonyldiimidazole. The magnetic nanoparticles were obtained separately via a coprecipitation mechanism involving inorganic iron salts in an alkaline environment. Four composite nanosponges were prepared by varying the content of magnetic nanoparticles (5 wt% and 10 wt%) in the cyclodextrin- and maltodextrin-based polymer matrix. The magnetic nanosponges were then characterised by FTIR, TGA, XRD, FESEM, and HRTEM analysis. The magnetic properties of the nanosponges were investigated via magnetisation curves collected at RT. Finally, the magnetic nanosponges were loaded with doxorubicin and tested as a drug delivery system. The nanosponges exhibited a loading capacity of approximately 3 wt%. Doxorubicin was released by the loaded nanosponges with sustained kinetics over a prolonged period of time.https://www.mdpi.com/2079-4991/12/5/754magnetic nanocompositesdextrin nanospongescyclodextrinmaltodextriniron oxide nanoparticlesdoxorubicin |
| spellingShingle | Fabrizio Caldera Roberto Nisticò Giuliana Magnacca Adrián Matencio Yousef Khazaei Monfared Francesco Trotta Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery Nanomaterials magnetic nanocomposites dextrin nanosponges cyclodextrin maltodextrin iron oxide nanoparticles doxorubicin |
| title | Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery |
| title_full | Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery |
| title_fullStr | Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery |
| title_full_unstemmed | Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery |
| title_short | Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery |
| title_sort | magnetic composites of dextrin based carbonate nanosponges and iron oxide nanoparticles with potential application in targeted drug delivery |
| topic | magnetic nanocomposites dextrin nanosponges cyclodextrin maltodextrin iron oxide nanoparticles doxorubicin |
| url | https://www.mdpi.com/2079-4991/12/5/754 |
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