Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study
We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [123I]β-CIT SPECT imaging to estimate basal ganglia DA transporter density in former...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2010-05-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996110000112 |
| _version_ | 1818675733426339840 |
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| author | Richard F. Seegal Kenneth L. Marek John P. Seibyl Danna L. Jennings Eric S. Molho Donald S. Higgins Stewart A. Factor Edward F. Fitzgerald Elaine A. Hills Susan A. Korrick Mary S. Wolff Richard F. Haase Andrew C. Todd Patrick Parsons Robert J. McCaffrey |
| author_facet | Richard F. Seegal Kenneth L. Marek John P. Seibyl Danna L. Jennings Eric S. Molho Donald S. Higgins Stewart A. Factor Edward F. Fitzgerald Elaine A. Hills Susan A. Korrick Mary S. Wolff Richard F. Haase Andrew C. Todd Patrick Parsons Robert J. McCaffrey |
| author_sort | Richard F. Seegal |
| collection | DOAJ |
| description | We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [123I]β-CIT SPECT imaging to estimate basal ganglia DA transporter density in former capacitor workers. Women, but not men, showed an inverse relationship between lipid-adjusted total serum PCB concentrations and DA transporter densities in the absence of differences in serum PCB concentrations. These sex differences may reflect age-related reductions in the levels of gonadal hormones since these hormones have been shown experimentally to alter response to DA neurotoxicants. These findings may aid in better understanding the roles that sex and age play in modifying central DA function following exposure, not only to PCBs, but also to other DA neurotoxicants as well as further elucidating the role of gonadal hormones in influencing the initiation and/or progression of neurodegenerative disorders. |
| first_indexed | 2024-12-17T08:32:16Z |
| format | Article |
| id | doaj.art-7d48a47f43104559b6da08d5180d95c5 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T08:32:16Z |
| publishDate | 2010-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-7d48a47f43104559b6da08d5180d95c52022-12-21T21:56:34ZengElsevierNeurobiology of Disease1095-953X2010-05-01382219225Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging studyRichard F. Seegal0Kenneth L. Marek1John P. Seibyl2Danna L. Jennings3Eric S. Molho4Donald S. Higgins5Stewart A. Factor6Edward F. Fitzgerald7Elaine A. Hills8Susan A. Korrick9Mary S. Wolff10Richard F. Haase11Andrew C. Todd12Patrick Parsons13Robert J. McCaffrey14Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Environmental Health Sciences, School of Public Health, University at Albany, Albany, NY, USA; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY, USA; Corresponding author. Wadsworth Center, New York State Department of Health, P.O. Box 509, Empire State Plaza, Albany, NY 12201-0509, USA. Fax: +1 518 473 2895.Institute for Neurodegenerative Disorders, New Haven, CT, USAInstitute for Neurodegenerative Disorders, New Haven, CT, USAInstitute for Neurodegenerative Disorders, New Haven, CT, USAParkinson's Disease and Movement Disorders Center of Albany Medical Center, Albany, NY, USAParkinson's Disease and Movement Disorders Center of Albany Medical Center, Albany, NY, USA; Neurology Section, Stratton VA Medical Center, Albany, NY, USADepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USADepartment of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, NY, USADepartment of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, NY, USADepartment of Environmental Health, Channing Laboratory, Harvard School of Public Health, Boston, MA, USADepartment of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USADepartment of Counseling Psychology, University at Albany, Albany, NY, USADepartment of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USAWadsworth Center, New York State Department of Health, Albany, NY, USADepartment of Psychology, University at Albany, Albany, NY, USAWe hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [123I]β-CIT SPECT imaging to estimate basal ganglia DA transporter density in former capacitor workers. Women, but not men, showed an inverse relationship between lipid-adjusted total serum PCB concentrations and DA transporter densities in the absence of differences in serum PCB concentrations. These sex differences may reflect age-related reductions in the levels of gonadal hormones since these hormones have been shown experimentally to alter response to DA neurotoxicants. These findings may aid in better understanding the roles that sex and age play in modifying central DA function following exposure, not only to PCBs, but also to other DA neurotoxicants as well as further elucidating the role of gonadal hormones in influencing the initiation and/or progression of neurodegenerative disorders.http://www.sciencedirect.com/science/article/pii/S0969996110000112Polychlorinated biphenyls (PCBs)Occupational exposureStriatal dopamine transporter (DAT)β-CIT imagingAdults |
| spellingShingle | Richard F. Seegal Kenneth L. Marek John P. Seibyl Danna L. Jennings Eric S. Molho Donald S. Higgins Stewart A. Factor Edward F. Fitzgerald Elaine A. Hills Susan A. Korrick Mary S. Wolff Richard F. Haase Andrew C. Todd Patrick Parsons Robert J. McCaffrey Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study Neurobiology of Disease Polychlorinated biphenyls (PCBs) Occupational exposure Striatal dopamine transporter (DAT) β-CIT imaging Adults |
| title | Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study |
| title_full | Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study |
| title_fullStr | Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study |
| title_full_unstemmed | Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study |
| title_short | Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study |
| title_sort | occupational exposure to pcbs reduces striatal dopamine transporter densities only in women a β cit imaging study |
| topic | Polychlorinated biphenyls (PCBs) Occupational exposure Striatal dopamine transporter (DAT) β-CIT imaging Adults |
| url | http://www.sciencedirect.com/science/article/pii/S0969996110000112 |
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