Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study

Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study

We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [123I]β-CIT SPECT imaging to estimate basal ganglia DA transporter density in former...

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Bibliographic Details
Main Authors: Richard F. Seegal, Kenneth L. Marek, John P. Seibyl, Danna L. Jennings, Eric S. Molho, Donald S. Higgins, Stewart A. Factor, Edward F. Fitzgerald, Elaine A. Hills, Susan A. Korrick, Mary S. Wolff, Richard F. Haase, Andrew C. Todd, Patrick Parsons, Robert J. McCaffrey
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Neurobiology of Disease
Subjects:
Polychlorinated biphenyls (PCBs)
Occupational exposure
Striatal dopamine transporter (DAT)
β-CIT imaging
Adults
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000112

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