Gestational Low Protein Diet Modulation on miRNA Transcriptome and Its Target During Fetal and Breastfeeding Nephrogenesis

Gestational Low Protein Diet Modulation on miRNA Transcriptome and Its Target During Fetal and Breastfeeding Nephrogenesis

BackgroundThe kidney ontogenesis is the most structurally affected by gestational protein restriction, reducing 28% of their functional units. The reduced nephron number is predictive of hypertension and cardiovascular dysfunctions that are generally observed in the adult age of most fetal programmi...

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Bibliographic Details
Main Authors: Letícia de Barros Sene, Gabriela Leme Lamana, Andre Schwambach Vieira, Wellerson Rodrigo Scarano, José Antônio Rocha Gontijo, Patrícia Aline Boer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
fetal programming
gestational low-protein intake
nephrogenesis
metanephric mesenchyme
low nephron number
miRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.648056/full

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