Development and validation of novel scoring system for the prediction of disease recurrence following resection of colorectal liver metastasis
Summary: Background: The aim of this study was to identify predictive factors for the recurrence of colorectal cancer liver metastasis (CRLM) and then to develop a corresponding novel scoring system that should improve the sensitivity of predicting recurrence in patients with CRLM. Methods: A total...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-02-01
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| Series: | Asian Journal of Surgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958419300296 |
| _version_ | 1811326933071298560 |
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| author | Wan-Joon Kim Tae-Wan Lim Sang-Hee Kang Pyoung-Jae Park Sae-Byeol Choi Sun-il Lee Byung-Wook Min Wan-Bae Kim |
| author_facet | Wan-Joon Kim Tae-Wan Lim Sang-Hee Kang Pyoung-Jae Park Sae-Byeol Choi Sun-il Lee Byung-Wook Min Wan-Bae Kim |
| author_sort | Wan-Joon Kim |
| collection | DOAJ |
| description | Summary: Background: The aim of this study was to identify predictive factors for the recurrence of colorectal cancer liver metastasis (CRLM) and then to develop a corresponding novel scoring system that should improve the sensitivity of predicting recurrence in patients with CRLM. Methods: A total of 295 consecutive CRLM patients were enrolled in our institution between January 2002 and December 2015. Multivariate analyses were performed to identify the variables associated with disease recurrence and established the novel scoring system based on it. Results: The scoring system considered seven variables: synchronosity, CA19-9 level, number of liver metastasis, largest size of liver metastasis, resection margin of hepatic lesion, neutrophil-to-lymphocyte ratio and prognostic nutritional index. The area under the curve of ROC was 0.824 (95% confidence interval 0.767–0.882); the sensitivity of our scoring system was 87.9%, specificity was 66.7%, positive predictive value was 20.6%, and negative predictive value was 20.9%. Conclusion: For patients with CRLM undergoing curative hepatic resection, our novel scoring system would improve the sensitivity for prediction of disease recurrence in Case of CRLM patients. Keywords: CA19-9, CRLM, Disease free survival, NLR, Scoring system |
| first_indexed | 2024-04-13T14:58:00Z |
| format | Article |
| id | doaj.art-7d49f816599c4c61a0313a26ff325450 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-04-13T14:58:00Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-7d49f816599c4c61a0313a26ff3254502022-12-22T02:42:23ZengElsevierAsian Journal of Surgery1015-95842020-02-01432438446Development and validation of novel scoring system for the prediction of disease recurrence following resection of colorectal liver metastasisWan-Joon Kim0Tae-Wan Lim1Sang-Hee Kang2Pyoung-Jae Park3Sae-Byeol Choi4Sun-il Lee5Byung-Wook Min6Wan-Bae Kim7Division of Hepatobiliary Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South KoreaDivision of Hepatobiliary Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South KoreaDivision of Colorectal Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South KoreaDivision of Transplantation Vascular Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South KoreaDivision of Hepatobiliary Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South KoreaDivision of Colorectal Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South KoreaDivision of Colorectal Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South KoreaDivision of Hepatobiliary Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea; Corresponding author. Division of Hepatobiliary Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, 148, Gurodong-ro, Guro-gu, Seoul 08308, South Korea. Fax: +82 2 2626 1148.Summary: Background: The aim of this study was to identify predictive factors for the recurrence of colorectal cancer liver metastasis (CRLM) and then to develop a corresponding novel scoring system that should improve the sensitivity of predicting recurrence in patients with CRLM. Methods: A total of 295 consecutive CRLM patients were enrolled in our institution between January 2002 and December 2015. Multivariate analyses were performed to identify the variables associated with disease recurrence and established the novel scoring system based on it. Results: The scoring system considered seven variables: synchronosity, CA19-9 level, number of liver metastasis, largest size of liver metastasis, resection margin of hepatic lesion, neutrophil-to-lymphocyte ratio and prognostic nutritional index. The area under the curve of ROC was 0.824 (95% confidence interval 0.767–0.882); the sensitivity of our scoring system was 87.9%, specificity was 66.7%, positive predictive value was 20.6%, and negative predictive value was 20.9%. Conclusion: For patients with CRLM undergoing curative hepatic resection, our novel scoring system would improve the sensitivity for prediction of disease recurrence in Case of CRLM patients. Keywords: CA19-9, CRLM, Disease free survival, NLR, Scoring systemhttp://www.sciencedirect.com/science/article/pii/S1015958419300296 |
| spellingShingle | Wan-Joon Kim Tae-Wan Lim Sang-Hee Kang Pyoung-Jae Park Sae-Byeol Choi Sun-il Lee Byung-Wook Min Wan-Bae Kim Development and validation of novel scoring system for the prediction of disease recurrence following resection of colorectal liver metastasis Asian Journal of Surgery |
| title | Development and validation of novel scoring system for the prediction of disease recurrence following resection of colorectal liver metastasis |
| title_full | Development and validation of novel scoring system for the prediction of disease recurrence following resection of colorectal liver metastasis |
| title_fullStr | Development and validation of novel scoring system for the prediction of disease recurrence following resection of colorectal liver metastasis |
| title_full_unstemmed | Development and validation of novel scoring system for the prediction of disease recurrence following resection of colorectal liver metastasis |
| title_short | Development and validation of novel scoring system for the prediction of disease recurrence following resection of colorectal liver metastasis |
| title_sort | development and validation of novel scoring system for the prediction of disease recurrence following resection of colorectal liver metastasis |
| url | http://www.sciencedirect.com/science/article/pii/S1015958419300296 |
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