Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing
Cutaneous wound healing affecting millions of people worldwide represents an unsolvable clinical issue that is frequently challenged by scar formation with dramatical pain, impaired mobility and disfigurement. Herein, we prepared a kind of light-sensitive decellularized dermal extracellular matrix-d...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423001850 |
| _version_ | 1797770747643428864 |
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| author | Yaling Yu Huimin Xiao Guoke Tang Hongshu Wang Junjie Shen Yi Sun Shuaiqun Wang Wei Kong Yimin Chai Xuanzhe Liu Xing Wang Gen Wen |
| author_facet | Yaling Yu Huimin Xiao Guoke Tang Hongshu Wang Junjie Shen Yi Sun Shuaiqun Wang Wei Kong Yimin Chai Xuanzhe Liu Xing Wang Gen Wen |
| author_sort | Yaling Yu |
| collection | DOAJ |
| description | Cutaneous wound healing affecting millions of people worldwide represents an unsolvable clinical issue that is frequently challenged by scar formation with dramatical pain, impaired mobility and disfigurement. Herein, we prepared a kind of light-sensitive decellularized dermal extracellular matrix-derived hydrogel with fast gelling performance, biomimetic porous microstructure and abundant bioactive functions. On account of its excellent cell biocompatibility, this ECM-derived hydrogel could induce a marked cellular infiltration and enhance the tube formation of HUVECs. In vivo experiments based upon excisional wound splinting model showed that the hydrogel prominently imparted skin wound healing, as evidenced by notably increased skin appendages and well-organized collagen expression, coupled with significantly enhanced angiogenesis. Moreover, the skin regeneration mediated by this bioactive hydrogel was promoted by an accelerated M1-to-M2 macrophage phenotype transition. Consequently, the decellularized dermal matrix-derived bioactive hydrogel orchestrates the entire skin healing microenvironment to promote wound healing and will be of high value in treatment of cutaneous wound healing. As such, this biomimetic ddECMMA hydrogel provides a promising versatile opinion for the clinical translation. |
| first_indexed | 2024-03-12T21:27:43Z |
| format | Article |
| id | doaj.art-7d4a292730254476b1ffac7e614b9f5f |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-12T21:27:43Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-7d4a292730254476b1ffac7e614b9f5f2023-07-28T04:26:45ZengElsevierMaterials Today Bio2590-00642023-08-0121100725Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healingYaling Yu0Huimin Xiao1Guoke Tang2Hongshu Wang3Junjie Shen4Yi Sun5Shuaiqun Wang6Wei Kong7Yimin Chai8Xuanzhe Liu9Xing Wang10Gen Wen11Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China; Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, ChinaDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China; College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, 201306, ChinaDepartment of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, ChinaDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, ChinaDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, ChinaDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, ChinaCollege of Information Engineering, Shanghai Maritime University, Shanghai, 201306, ChinaCollege of Information Engineering, Shanghai Maritime University, Shanghai, 201306, ChinaDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China; Corresponding author.Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China; Corresponding author.Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Corresponding author. Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China; Corresponding author.Cutaneous wound healing affecting millions of people worldwide represents an unsolvable clinical issue that is frequently challenged by scar formation with dramatical pain, impaired mobility and disfigurement. Herein, we prepared a kind of light-sensitive decellularized dermal extracellular matrix-derived hydrogel with fast gelling performance, biomimetic porous microstructure and abundant bioactive functions. On account of its excellent cell biocompatibility, this ECM-derived hydrogel could induce a marked cellular infiltration and enhance the tube formation of HUVECs. In vivo experiments based upon excisional wound splinting model showed that the hydrogel prominently imparted skin wound healing, as evidenced by notably increased skin appendages and well-organized collagen expression, coupled with significantly enhanced angiogenesis. Moreover, the skin regeneration mediated by this bioactive hydrogel was promoted by an accelerated M1-to-M2 macrophage phenotype transition. Consequently, the decellularized dermal matrix-derived bioactive hydrogel orchestrates the entire skin healing microenvironment to promote wound healing and will be of high value in treatment of cutaneous wound healing. As such, this biomimetic ddECMMA hydrogel provides a promising versatile opinion for the clinical translation.http://www.sciencedirect.com/science/article/pii/S2590006423001850DecellularizationDermal tissuePhoto-responsibilityImmunomodulationWound healing |
| spellingShingle | Yaling Yu Huimin Xiao Guoke Tang Hongshu Wang Junjie Shen Yi Sun Shuaiqun Wang Wei Kong Yimin Chai Xuanzhe Liu Xing Wang Gen Wen Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing Materials Today Bio Decellularization Dermal tissue Photo-responsibility Immunomodulation Wound healing |
| title | Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing |
| title_full | Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing |
| title_fullStr | Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing |
| title_full_unstemmed | Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing |
| title_short | Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing |
| title_sort | biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing |
| topic | Decellularization Dermal tissue Photo-responsibility Immunomodulation Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423001850 |
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