Electrocatalytic Determination of Isoniazid by a Glassy Carbon Electrode Modified with Poly (Eriochrome Black T)
In this work poly eriochrome black T (EBT) was electrochemically synthesized on the glassy carbon electrode as electrode modifier. On the modified electrode, voltammetric behavior of isoniazid (INH) was investigated. The poly (EBT)-modified glassy carbon electrode has excellent electrocatalytic abil...
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Iranian Chemical Society
2017-06-01
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Series: | Analytical and Bioanalytical Chemistry Research |
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Online Access: | http://www.analchemres.org/article_40874_a68861fa52cf1889c3cdcf9d5f06cb48.pdf |
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author | Karim Asadpour-Zeynali Venus Baghalabadi |
author_facet | Karim Asadpour-Zeynali Venus Baghalabadi |
author_sort | Karim Asadpour-Zeynali |
collection | DOAJ |
description | In this work poly eriochrome black T (EBT) was electrochemically synthesized on the glassy carbon electrode as electrode modifier. On the modified electrode, voltammetric behavior of isoniazid (INH) was investigated. The poly (EBT)-modified glassy carbon electrode has excellent electrocatalytic ability for the electrooxidation of isoniazid. This fact was appeared as a reduced overpotential of INH oxidation in a wide operational pH range from 2 to 13. It has been found that the catalytic peak current depends on the concentration of INH and solution pH. The number of electrons involved in the rate determining step was found 1. The diffusion coefficient of isoniazid was also estimated using chronoamperometry technique. The experimental results showed that the mediated oxidation peak current of isoniazid is linearly dependent on the concentration of isoniazid in the ranges of 8.0 × 10-6 – 1.18 × 10-3 M and 2.90 × 10-5 M – 1.67× 10-3 M with differential pulse voltammetry (DPV) and amperometry methods, respectively. The detection limits (S/N = 3) were found to be 6.0 μM and 16.4 μM by DPV and amperometry methods, respectively. This developed method was applied to the determination of isoniazid in tablet samples with satisfactory results. |
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spelling | doaj.art-7d4afc20431944fabed6fb6f404d36fa2022-12-21T23:16:11ZengIranian Chemical SocietyAnalytical and Bioanalytical Chemistry Research2383-093X2383-093X2017-06-0141314010.22036/abcr.2017.4087440874Electrocatalytic Determination of Isoniazid by a Glassy Carbon Electrode Modified with Poly (Eriochrome Black T)Karim Asadpour-Zeynali0Venus Baghalabadi1Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, IranDepartment of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, IranIn this work poly eriochrome black T (EBT) was electrochemically synthesized on the glassy carbon electrode as electrode modifier. On the modified electrode, voltammetric behavior of isoniazid (INH) was investigated. The poly (EBT)-modified glassy carbon electrode has excellent electrocatalytic ability for the electrooxidation of isoniazid. This fact was appeared as a reduced overpotential of INH oxidation in a wide operational pH range from 2 to 13. It has been found that the catalytic peak current depends on the concentration of INH and solution pH. The number of electrons involved in the rate determining step was found 1. The diffusion coefficient of isoniazid was also estimated using chronoamperometry technique. The experimental results showed that the mediated oxidation peak current of isoniazid is linearly dependent on the concentration of isoniazid in the ranges of 8.0 × 10-6 – 1.18 × 10-3 M and 2.90 × 10-5 M – 1.67× 10-3 M with differential pulse voltammetry (DPV) and amperometry methods, respectively. The detection limits (S/N = 3) were found to be 6.0 μM and 16.4 μM by DPV and amperometry methods, respectively. This developed method was applied to the determination of isoniazid in tablet samples with satisfactory results.http://www.analchemres.org/article_40874_a68861fa52cf1889c3cdcf9d5f06cb48.pdfIsoniazidPoly (eriochrome black T) modified electrodeVoltammetric behaviorDetermination |
spellingShingle | Karim Asadpour-Zeynali Venus Baghalabadi Electrocatalytic Determination of Isoniazid by a Glassy Carbon Electrode Modified with Poly (Eriochrome Black T) Analytical and Bioanalytical Chemistry Research Isoniazid Poly (eriochrome black T) modified electrode Voltammetric behavior Determination |
title | Electrocatalytic Determination of Isoniazid by a Glassy Carbon Electrode Modified with Poly (Eriochrome Black T) |
title_full | Electrocatalytic Determination of Isoniazid by a Glassy Carbon Electrode Modified with Poly (Eriochrome Black T) |
title_fullStr | Electrocatalytic Determination of Isoniazid by a Glassy Carbon Electrode Modified with Poly (Eriochrome Black T) |
title_full_unstemmed | Electrocatalytic Determination of Isoniazid by a Glassy Carbon Electrode Modified with Poly (Eriochrome Black T) |
title_short | Electrocatalytic Determination of Isoniazid by a Glassy Carbon Electrode Modified with Poly (Eriochrome Black T) |
title_sort | electrocatalytic determination of isoniazid by a glassy carbon electrode modified with poly eriochrome black t |
topic | Isoniazid Poly (eriochrome black T) modified electrode Voltammetric behavior Determination |
url | http://www.analchemres.org/article_40874_a68861fa52cf1889c3cdcf9d5f06cb48.pdf |
work_keys_str_mv | AT karimasadpourzeynali electrocatalyticdeterminationofisoniazidbyaglassycarbonelectrodemodifiedwithpolyeriochromeblackt AT venusbaghalabadi electrocatalyticdeterminationofisoniazidbyaglassycarbonelectrodemodifiedwithpolyeriochromeblackt |