CRP Serum Levels Are Associated with High Cardiometabolic Risk and Clinical Disease Activity in Systemic Lupus Erythematosus Patients
Systemic lupus erythematosus (SLE) patients have a higher frequency of cardiovascular risk factors such as high C-reactive protein (CRP) levels than the general population. CRP is considered a cardiovascular disease marker that could be related to SLE clinical disease activity. This study aimed to a...
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MDPI AG
2022-03-01
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author | Karen Pesqueda-Cendejas Isela Parra-Rojas Paulina E. Mora-García Margarita Montoya-Buelna Adolfo I. Ruiz-Ballesteros Mónica R. Meza-Meza Bertha Campos-López Melissa Rivera-Escoto Barbara Vizmanos-Lamotte Sergio Cerpa-Cruz Ulises de la Cruz-Mosso |
author_facet | Karen Pesqueda-Cendejas Isela Parra-Rojas Paulina E. Mora-García Margarita Montoya-Buelna Adolfo I. Ruiz-Ballesteros Mónica R. Meza-Meza Bertha Campos-López Melissa Rivera-Escoto Barbara Vizmanos-Lamotte Sergio Cerpa-Cruz Ulises de la Cruz-Mosso |
author_sort | Karen Pesqueda-Cendejas |
collection | DOAJ |
description | Systemic lupus erythematosus (SLE) patients have a higher frequency of cardiovascular risk factors such as high C-reactive protein (CRP) levels than the general population. CRP is considered a cardiovascular disease marker that could be related to SLE clinical disease activity. This study aimed to assess the association between CRP with cardiometabolic risk and clinical disease activity in SLE patients. A comparative cross-sectional study was conducted in 176 female SLE patients and 175 control subjects (CS) with median ages of 38 and 33 years, respectively; SLE patients were classified by the 1997 SLE-ACR criteria, and the clinical disease activity by the Mexican-SLEDAI (Mex-SLEDAI). CRP and lipid profile (triglycerides, cholesterol, HDL-C, and LDL-C) were quantified by turbidimetry and colorimetric-enzymatic assays, respectively. SLE patients had higher CRP levels than CS (SLE: 5 mg/L vs. CS = 1.1 mg/L; <i>p</i> < 0.001). In SLE patients, CRP levels ≥ 3 mg/L were associated with a higher risk of cardiometabolic risk status assessed by LAP index (OR = 3.01; IC: 1.04–8.7; <i>p</i> = 0.04), triglycerides/HDL-C index (OR = 5.2; IC: 2.1–12.8; <i>p</i> < 0.001), Kannel index (OR = 3.1; IC: 1.1–8.1; <i>p</i> = 0.03), Castelli index (OR = 6.6; IC: 2.5–17.8; <i>p</i> < 0.001), and high clinical disease activity (OR = 2.5: IC: 1.03–6.2; <i>p</i> = 0.04; and β coefficient = 5.8; IC: 2.5–9.4; R<sup>2</sup> = 0.15; <i>p</i> = 0.001). In conclusion, high CRP levels were associated with high cardiometabolic risk and clinical disease activity in SLE patients. |
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language | English |
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spelling | doaj.art-7d4bbc29dd8141d5a0083c2498e8003b2023-11-30T23:27:43ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01117184910.3390/jcm11071849CRP Serum Levels Are Associated with High Cardiometabolic Risk and Clinical Disease Activity in Systemic Lupus Erythematosus PatientsKaren Pesqueda-Cendejas0Isela Parra-Rojas1Paulina E. Mora-García2Margarita Montoya-Buelna3Adolfo I. Ruiz-Ballesteros4Mónica R. Meza-Meza5Bertha Campos-López6Melissa Rivera-Escoto7Barbara Vizmanos-Lamotte8Sergio Cerpa-Cruz9Ulises de la Cruz-Mosso10Proyecto Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoProyecto Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoProyecto Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoProyecto Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoProyecto Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoProyecto Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoProyecto Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoProyecto Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoProyecto Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoDepartamento de Reumatología, O.P.D. Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, MexicoProyecto Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoSystemic lupus erythematosus (SLE) patients have a higher frequency of cardiovascular risk factors such as high C-reactive protein (CRP) levels than the general population. CRP is considered a cardiovascular disease marker that could be related to SLE clinical disease activity. This study aimed to assess the association between CRP with cardiometabolic risk and clinical disease activity in SLE patients. A comparative cross-sectional study was conducted in 176 female SLE patients and 175 control subjects (CS) with median ages of 38 and 33 years, respectively; SLE patients were classified by the 1997 SLE-ACR criteria, and the clinical disease activity by the Mexican-SLEDAI (Mex-SLEDAI). CRP and lipid profile (triglycerides, cholesterol, HDL-C, and LDL-C) were quantified by turbidimetry and colorimetric-enzymatic assays, respectively. SLE patients had higher CRP levels than CS (SLE: 5 mg/L vs. CS = 1.1 mg/L; <i>p</i> < 0.001). In SLE patients, CRP levels ≥ 3 mg/L were associated with a higher risk of cardiometabolic risk status assessed by LAP index (OR = 3.01; IC: 1.04–8.7; <i>p</i> = 0.04), triglycerides/HDL-C index (OR = 5.2; IC: 2.1–12.8; <i>p</i> < 0.001), Kannel index (OR = 3.1; IC: 1.1–8.1; <i>p</i> = 0.03), Castelli index (OR = 6.6; IC: 2.5–17.8; <i>p</i> < 0.001), and high clinical disease activity (OR = 2.5: IC: 1.03–6.2; <i>p</i> = 0.04; and β coefficient = 5.8; IC: 2.5–9.4; R<sup>2</sup> = 0.15; <i>p</i> = 0.001). In conclusion, high CRP levels were associated with high cardiometabolic risk and clinical disease activity in SLE patients.https://www.mdpi.com/2077-0383/11/7/1849C-reactive proteincardiovascular risksystemic lupus erythematosusclinical activitylipid profilebody composition |
spellingShingle | Karen Pesqueda-Cendejas Isela Parra-Rojas Paulina E. Mora-García Margarita Montoya-Buelna Adolfo I. Ruiz-Ballesteros Mónica R. Meza-Meza Bertha Campos-López Melissa Rivera-Escoto Barbara Vizmanos-Lamotte Sergio Cerpa-Cruz Ulises de la Cruz-Mosso CRP Serum Levels Are Associated with High Cardiometabolic Risk and Clinical Disease Activity in Systemic Lupus Erythematosus Patients Journal of Clinical Medicine C-reactive protein cardiovascular risk systemic lupus erythematosus clinical activity lipid profile body composition |
title | CRP Serum Levels Are Associated with High Cardiometabolic Risk and Clinical Disease Activity in Systemic Lupus Erythematosus Patients |
title_full | CRP Serum Levels Are Associated with High Cardiometabolic Risk and Clinical Disease Activity in Systemic Lupus Erythematosus Patients |
title_fullStr | CRP Serum Levels Are Associated with High Cardiometabolic Risk and Clinical Disease Activity in Systemic Lupus Erythematosus Patients |
title_full_unstemmed | CRP Serum Levels Are Associated with High Cardiometabolic Risk and Clinical Disease Activity in Systemic Lupus Erythematosus Patients |
title_short | CRP Serum Levels Are Associated with High Cardiometabolic Risk and Clinical Disease Activity in Systemic Lupus Erythematosus Patients |
title_sort | crp serum levels are associated with high cardiometabolic risk and clinical disease activity in systemic lupus erythematosus patients |
topic | C-reactive protein cardiovascular risk systemic lupus erythematosus clinical activity lipid profile body composition |
url | https://www.mdpi.com/2077-0383/11/7/1849 |
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