Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication
Abstract Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed to clarify the non-invasive factors associated with HCC following sustained virolog...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-05492-5 |
| _version_ | 1818333150456053760 |
|---|---|
| author | Masato Nakai Yoshiya Yamamoto Masaru Baba Goki Suda Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Taku Shigesawa Kazuharu Suzuki Akihisa Nakamura Takuya Sho Kenichi Morikawa Koji Ogawa Ken Furuya Naoya Sakamoto |
| author_facet | Masato Nakai Yoshiya Yamamoto Masaru Baba Goki Suda Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Taku Shigesawa Kazuharu Suzuki Akihisa Nakamura Takuya Sho Kenichi Morikawa Koji Ogawa Ken Furuya Naoya Sakamoto |
| author_sort | Masato Nakai |
| collection | DOAJ |
| description | Abstract Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed to clarify the non-invasive factors associated with HCC following sustained virological response (SVR) and to identify the low-risk group. 567 patients without history of HCC who achieved SVR at 24 weeks (SVR24) after IFN-free treatment were retrospectively analyzed. The cumulative incidence of HCC and the risk factors were examined using pre-treatment and SVR24 data. The median observation period was 50.2 months. Thirty cases of HCC were observed, and the 4-year cumulative incidence of HCC was 5.9%. In multivariate analysis, significant pre-treatment factors were age ≥ 71 years (hazard ratio [HR]: 3.402) and LSM ≥ 9.2 kPa (HR: 6.328); SVR24 factors were age ≥ 71 years (HR: 2.689) and LSM ≥ 8.4 kPa (HR: 6.642). In cases with age < 71 years and LSM < 8.4 kPa at the time of SVR24, the 4-year cumulative incidence of HCC was as low as 1.1%. Both pre-treatment LSM (≥ 9.2 kPa) and SVR24 LSM (≥ 8.4 kPa) and age (≥ 71 years) are useful in predicting the risk of HCC after SVR with IFN-free treatment. Identification of low-risk individuals may improve the efficiency of follow-up. |
| first_indexed | 2024-12-13T13:47:04Z |
| format | Article |
| id | doaj.art-7d4cef0345414ea29ae87e92e6a05592 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T13:47:04Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7d4cef0345414ea29ae87e92e6a055922022-12-21T23:43:22ZengNature PortfolioScientific Reports2045-23222022-01-0112111010.1038/s41598-022-05492-5Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradicationMasato Nakai0Yoshiya Yamamoto1Masaru Baba2Goki Suda3Akinori Kubo4Yoshimasa Tokuchi5Takashi Kitagataya6Ren Yamada7Taku Shigesawa8Kazuharu Suzuki9Akihisa Nakamura10Takuya Sho11Kenichi Morikawa12Koji Ogawa13Ken Furuya14Naoya Sakamoto15Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology, Hakodate Municipal HospitalDepartment of Gastroenterology, JCHO Hokkaido HospitalDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology, Hakodate Municipal HospitalDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterology, JCHO Hokkaido HospitalDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido UniversityAbstract Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed to clarify the non-invasive factors associated with HCC following sustained virological response (SVR) and to identify the low-risk group. 567 patients without history of HCC who achieved SVR at 24 weeks (SVR24) after IFN-free treatment were retrospectively analyzed. The cumulative incidence of HCC and the risk factors were examined using pre-treatment and SVR24 data. The median observation period was 50.2 months. Thirty cases of HCC were observed, and the 4-year cumulative incidence of HCC was 5.9%. In multivariate analysis, significant pre-treatment factors were age ≥ 71 years (hazard ratio [HR]: 3.402) and LSM ≥ 9.2 kPa (HR: 6.328); SVR24 factors were age ≥ 71 years (HR: 2.689) and LSM ≥ 8.4 kPa (HR: 6.642). In cases with age < 71 years and LSM < 8.4 kPa at the time of SVR24, the 4-year cumulative incidence of HCC was as low as 1.1%. Both pre-treatment LSM (≥ 9.2 kPa) and SVR24 LSM (≥ 8.4 kPa) and age (≥ 71 years) are useful in predicting the risk of HCC after SVR with IFN-free treatment. Identification of low-risk individuals may improve the efficiency of follow-up.https://doi.org/10.1038/s41598-022-05492-5 |
| spellingShingle | Masato Nakai Yoshiya Yamamoto Masaru Baba Goki Suda Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Taku Shigesawa Kazuharu Suzuki Akihisa Nakamura Takuya Sho Kenichi Morikawa Koji Ogawa Ken Furuya Naoya Sakamoto Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication Scientific Reports |
| title | Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication |
| title_full | Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication |
| title_fullStr | Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication |
| title_full_unstemmed | Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication |
| title_short | Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication |
| title_sort | prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis c virus eradication |
| url | https://doi.org/10.1038/s41598-022-05492-5 |
| work_keys_str_mv | AT masatonakai predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT yoshiyayamamoto predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT masarubaba predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT gokisuda predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT akinorikubo predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT yoshimasatokuchi predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT takashikitagataya predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT renyamada predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT takushigesawa predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT kazuharusuzuki predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT akihisanakamura predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT takuyasho predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT kenichimorikawa predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT kojiogawa predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT kenfuruya predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication AT naoyasakamoto predictionofhepatocellularcarcinomausingageandliverstiffnessontransientelastographyafterhepatitiscviruseradication |