The transcription factor Cux1 regulates dendritic morphology of cortical pyramidal neurons.
In the murine cerebral cortex, mammalian homologues of the Cux family transcription factors, Cux1 and Cux2, have been identified as restricted molecular markers for the upper layer (II-IV) pyramidal neurons. However, their functions in cortical development are largely unknown. Here we report that in...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2868054?pdf=render |
| _version_ | 1811274408380071936 |
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| author | Ning Li Chun-Tao Zhao Ying Wang Xiao-Bing Yuan |
| author_facet | Ning Li Chun-Tao Zhao Ying Wang Xiao-Bing Yuan |
| author_sort | Ning Li |
| collection | DOAJ |
| description | In the murine cerebral cortex, mammalian homologues of the Cux family transcription factors, Cux1 and Cux2, have been identified as restricted molecular markers for the upper layer (II-IV) pyramidal neurons. However, their functions in cortical development are largely unknown. Here we report that increasing the intracellular level of Cux1, but not Cux2, reduced the dendritic complexity of cultured cortical pyramidal neurons. Consistently, reducing the expression of Cux1 promoted the dendritic arborization in these pyramidal neurons. This effect required the existence of the DNA-binding domains, hence the transcriptional passive repression activity of Cux1. Analysis of downstream signals suggested that Cux1 regulates dendrite development primarily through suppressing the expression of the cyclin-dependent kinase inhibitor p27(Kip1), and RhoA may mediate the regulation of dendritic complexity by Cux1 and p27. Thus, Cux1 functions as a negative regulator of dendritic complexity for cortical pyramidal neurons. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T23:18:22Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7d4e0cd1c4f144c8be9a83fd9a2d9ac92022-12-22T03:12:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-0155e1059610.1371/journal.pone.0010596The transcription factor Cux1 regulates dendritic morphology of cortical pyramidal neurons.Ning LiChun-Tao ZhaoYing WangXiao-Bing YuanIn the murine cerebral cortex, mammalian homologues of the Cux family transcription factors, Cux1 and Cux2, have been identified as restricted molecular markers for the upper layer (II-IV) pyramidal neurons. However, their functions in cortical development are largely unknown. Here we report that increasing the intracellular level of Cux1, but not Cux2, reduced the dendritic complexity of cultured cortical pyramidal neurons. Consistently, reducing the expression of Cux1 promoted the dendritic arborization in these pyramidal neurons. This effect required the existence of the DNA-binding domains, hence the transcriptional passive repression activity of Cux1. Analysis of downstream signals suggested that Cux1 regulates dendrite development primarily through suppressing the expression of the cyclin-dependent kinase inhibitor p27(Kip1), and RhoA may mediate the regulation of dendritic complexity by Cux1 and p27. Thus, Cux1 functions as a negative regulator of dendritic complexity for cortical pyramidal neurons.http://europepmc.org/articles/PMC2868054?pdf=render |
| spellingShingle | Ning Li Chun-Tao Zhao Ying Wang Xiao-Bing Yuan The transcription factor Cux1 regulates dendritic morphology of cortical pyramidal neurons. PLoS ONE |
| title | The transcription factor Cux1 regulates dendritic morphology of cortical pyramidal neurons. |
| title_full | The transcription factor Cux1 regulates dendritic morphology of cortical pyramidal neurons. |
| title_fullStr | The transcription factor Cux1 regulates dendritic morphology of cortical pyramidal neurons. |
| title_full_unstemmed | The transcription factor Cux1 regulates dendritic morphology of cortical pyramidal neurons. |
| title_short | The transcription factor Cux1 regulates dendritic morphology of cortical pyramidal neurons. |
| title_sort | transcription factor cux1 regulates dendritic morphology of cortical pyramidal neurons |
| url | http://europepmc.org/articles/PMC2868054?pdf=render |
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