Effects of inflammation on myopia: evidence and potential mechanisms
As the most common type of refractive error, myopia has become one of the leading causes of visual impairment. With the increasing prevalence of myopia, there is a growing need to better understand the factors involved in its development. Inflammation, one of the most fundamental pathophysiological...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260592/full |
| _version_ | 1797668203043749888 |
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| author | Ran Xu Ran Xu Jing Zheng Jing Zheng Longqian Liu Longqian Liu Wenqiu Zhang Wenqiu Zhang |
| author_facet | Ran Xu Ran Xu Jing Zheng Jing Zheng Longqian Liu Longqian Liu Wenqiu Zhang Wenqiu Zhang |
| author_sort | Ran Xu |
| collection | DOAJ |
| description | As the most common type of refractive error, myopia has become one of the leading causes of visual impairment. With the increasing prevalence of myopia, there is a growing need to better understand the factors involved in its development. Inflammation, one of the most fundamental pathophysiological processes in humans, is a rapid response triggered by harmful stimuli and conditions. Although controlled inflammatory responses are necessary, over-activated inflammation is the common soil for many diseases. The impact of inflammation on myopia has received rising attention in recent years. Elevated inflammation may contribute to myopia progression either directly or indirectly by inducing scleral remodeling, and myopia development may also increase ocular inflammation. This article provides a comprehensive review of the interplay between inflammation and myopia and the potential biological mechanisms, which may present new targets for understanding the pathology of myopia and developing myopia therapies. |
| first_indexed | 2024-03-11T20:25:24Z |
| format | Article |
| id | doaj.art-7d4f15d427e64bbc98ee4f87504a9c1b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T20:25:24Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7d4f15d427e64bbc98ee4f87504a9c1b2023-10-02T15:00:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12605921260592Effects of inflammation on myopia: evidence and potential mechanismsRan Xu0Ran Xu1Jing Zheng2Jing Zheng3Longqian Liu4Longqian Liu5Wenqiu Zhang6Wenqiu Zhang7Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu, ChinaAs the most common type of refractive error, myopia has become one of the leading causes of visual impairment. With the increasing prevalence of myopia, there is a growing need to better understand the factors involved in its development. Inflammation, one of the most fundamental pathophysiological processes in humans, is a rapid response triggered by harmful stimuli and conditions. Although controlled inflammatory responses are necessary, over-activated inflammation is the common soil for many diseases. The impact of inflammation on myopia has received rising attention in recent years. Elevated inflammation may contribute to myopia progression either directly or indirectly by inducing scleral remodeling, and myopia development may also increase ocular inflammation. This article provides a comprehensive review of the interplay between inflammation and myopia and the potential biological mechanisms, which may present new targets for understanding the pathology of myopia and developing myopia therapies.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260592/fullmyopiainflammationanti-inflammatory drugsimmune diseasesscleral remodeling |
| spellingShingle | Ran Xu Ran Xu Jing Zheng Jing Zheng Longqian Liu Longqian Liu Wenqiu Zhang Wenqiu Zhang Effects of inflammation on myopia: evidence and potential mechanisms Frontiers in Immunology myopia inflammation anti-inflammatory drugs immune diseases scleral remodeling |
| title | Effects of inflammation on myopia: evidence and potential mechanisms |
| title_full | Effects of inflammation on myopia: evidence and potential mechanisms |
| title_fullStr | Effects of inflammation on myopia: evidence and potential mechanisms |
| title_full_unstemmed | Effects of inflammation on myopia: evidence and potential mechanisms |
| title_short | Effects of inflammation on myopia: evidence and potential mechanisms |
| title_sort | effects of inflammation on myopia evidence and potential mechanisms |
| topic | myopia inflammation anti-inflammatory drugs immune diseases scleral remodeling |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260592/full |
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