An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic Dissection
One of the highest mortality rates of cardiovascular diseases is aortic dissections with challenging treatment options. Currently, less study has been conducted in developing in vitro patient-specific Type B aortic dissection models, which mimic physiological flow conditions along the true and false...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.797829/full |
| _version_ | 1818156946670223360 |
|---|---|
| author | Liam Morris Liam Morris Liam Morris Liam Morris Paul Tierney Paul Tierney Niamh Hynes Sherif Sultan Sherif Sultan |
| author_facet | Liam Morris Liam Morris Liam Morris Liam Morris Paul Tierney Paul Tierney Niamh Hynes Sherif Sultan Sherif Sultan |
| author_sort | Liam Morris |
| collection | DOAJ |
| description | One of the highest mortality rates of cardiovascular diseases is aortic dissections with challenging treatment options. Currently, less study has been conducted in developing in vitro patient-specific Type B aortic dissection models, which mimic physiological flow conditions along the true and false lumens separated by a dissection flap with multiple entry and exit tears. A patient-specific Stanford Type B aortic dissection scan was replicated by an in-house manufactured automatic injection moulding system and a novel modelling technique for creating the ascending aorta, aortic arch, and descending aorta incorporating arterial branching, the true/false lumens, and dissection flap with entry and exit intimal tears. The physiological flowrates and pressure values were monitored, which identified jet stream fluid flows entering and exiting the dissection tears. Pressure in the aorta’s true lumen region was controlled at 125/85 mmHg for systolic and diastolic values. Pressure values were obtained in eight sections along the false lumen using a pressure transducer. The true lumen systolic pressure varied from 122 to 128 mmHg along the length. Flow patterns were monitored by ultrasound along 12 sections. Detailed images obtained from the ultrasound transducer probe showed varied flow patterns with one or multiple jet steam vortices along the aorta model. The dissection flap movement was assessed at four sections of the patient-specific aorta model. The displacement values of the flap varied from 0.5 to 3 mm along the model. This model provides a unique insight into aortic dissection flow patterns and pressure distributions. This dissection phantom model can be used to assess various treatment options based on the surgical, endovascular, or hybrid techniques. |
| first_indexed | 2024-12-11T15:06:23Z |
| format | Article |
| id | doaj.art-7d4f18b936474b54be884298f59b692b |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-11T15:06:23Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-7d4f18b936474b54be884298f59b692b2022-12-22T01:00:53ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-03-01910.3389/fcvm.2022.797829797829An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic DissectionLiam Morris0Liam Morris1Liam Morris2Liam Morris3Paul Tierney4Paul Tierney5Niamh Hynes6Sherif Sultan7Sherif Sultan8Galway-Mayo Institute of Technology, Galway, IrelandGalway Medical Technology Centre, Department of Mechanical and Industrial Engineering, Galway-Mayo Institute of Technology, Galway, IrelandMedical and Engineering Technology Centre, Department of Mechanical and Industrial Engineering, Galway-Mayo Institute of Technology, Galway, IrelandLero – Science Foundation Ireland Research Centre for Software, Galway-Mayo Institute of Technology, Galway, IrelandGalway Medical Technology Centre, Department of Mechanical and Industrial Engineering, Galway-Mayo Institute of Technology, Galway, IrelandMedical and Engineering Technology Centre, Department of Mechanical and Industrial Engineering, Galway-Mayo Institute of Technology, Galway, IrelandCÚRAM, National University of Ireland, Galway, IrelandWestern Vascular Institute, Department of Vascular and Endovascular Surgery, University College Hospital Galway, Galway, IrelandDepartment of Vascular and Endovascular Surgery, Galway Clinic, Royal College of Surgeons in Ireland, Doughiska, IrelandOne of the highest mortality rates of cardiovascular diseases is aortic dissections with challenging treatment options. Currently, less study has been conducted in developing in vitro patient-specific Type B aortic dissection models, which mimic physiological flow conditions along the true and false lumens separated by a dissection flap with multiple entry and exit tears. A patient-specific Stanford Type B aortic dissection scan was replicated by an in-house manufactured automatic injection moulding system and a novel modelling technique for creating the ascending aorta, aortic arch, and descending aorta incorporating arterial branching, the true/false lumens, and dissection flap with entry and exit intimal tears. The physiological flowrates and pressure values were monitored, which identified jet stream fluid flows entering and exiting the dissection tears. Pressure in the aorta’s true lumen region was controlled at 125/85 mmHg for systolic and diastolic values. Pressure values were obtained in eight sections along the false lumen using a pressure transducer. The true lumen systolic pressure varied from 122 to 128 mmHg along the length. Flow patterns were monitored by ultrasound along 12 sections. Detailed images obtained from the ultrasound transducer probe showed varied flow patterns with one or multiple jet steam vortices along the aorta model. The dissection flap movement was assessed at four sections of the patient-specific aorta model. The displacement values of the flap varied from 0.5 to 3 mm along the model. This model provides a unique insight into aortic dissection flow patterns and pressure distributions. This dissection phantom model can be used to assess various treatment options based on the surgical, endovascular, or hybrid techniques.https://www.frontiersin.org/articles/10.3389/fcvm.2022.797829/fullaortic dissectionin vitro testingphantom modeltrue and false lumensblood pressureflow patterns |
| spellingShingle | Liam Morris Liam Morris Liam Morris Liam Morris Paul Tierney Paul Tierney Niamh Hynes Sherif Sultan Sherif Sultan An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic Dissection Frontiers in Cardiovascular Medicine aortic dissection in vitro testing phantom model true and false lumens blood pressure flow patterns |
| title | An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic Dissection |
| title_full | An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic Dissection |
| title_fullStr | An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic Dissection |
| title_full_unstemmed | An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic Dissection |
| title_short | An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic Dissection |
| title_sort | in vitro assessment of the haemodynamic features occurring within the true and false lumens separated by a dissection flap for a patient specific type b aortic dissection |
| topic | aortic dissection in vitro testing phantom model true and false lumens blood pressure flow patterns |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.797829/full |
| work_keys_str_mv | AT liammorris aninvitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT liammorris aninvitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT liammorris aninvitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT liammorris aninvitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT paultierney aninvitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT paultierney aninvitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT niamhhynes aninvitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT sherifsultan aninvitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT sherifsultan aninvitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT liammorris invitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT liammorris invitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT liammorris invitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT liammorris invitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT paultierney invitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT paultierney invitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT niamhhynes invitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT sherifsultan invitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection AT sherifsultan invitroassessmentofthehaemodynamicfeaturesoccurringwithinthetrueandfalselumensseparatedbyadissectionflapforapatientspecifictypebaorticdissection |