Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

Abstract Here, we report an experimental setup to benchmark different receptors for targeted therapeutic antibody delivery at the blood–brain barrier. We used brain capillary endothelial-like cells derived from induced pluripotent stem cells (hiPSC-BECs) as a model system and compared them to colon...

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Bibliographic Details
Main Authors: Mikkel Roland Holst, Nienke Marije de Wit, Burak Ozgür, Andreas Brachner, Kathrine Hyldig, Antje Appelt-Menzel, Hannah Sleven, Zameel Cader, Helga Eveline de Vries, Winfried Neuhaus, Allan Jensen, Birger Brodin, Morten Schallburg Nielsen
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood‒brain barrier
Receptor-mediated transcytosis
Transferrin receptor
Sortilin
CD133
Podocalyxin
Online Access:https://doi.org/10.1186/s12987-023-00480-x

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