Study The Effects of 5 Selenocyantouracil Compound on The liver and Kidney of Male Rats After Acetaminophen-Induced Liver Injury
Selenium compounds have long been assumed to protect organs against inflammation and cancer development by reducing oxidative stress. Drug-induced liver injury is a common side effect of many medications, with main symptoms ranging from an increase in asymptomatic liver enzymes to liver failure suc...
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2024-03-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2263 |
| _version_ | 1797236586850549760 |
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| author | Sahar Muayad Noori Nadheerah Falih Neamah Shaker Abdalsalim Al-Jadaan |
| author_facet | Sahar Muayad Noori Nadheerah Falih Neamah Shaker Abdalsalim Al-Jadaan |
| author_sort | Sahar Muayad Noori |
| collection | DOAJ |
| description |
Selenium compounds have long been assumed to protect organs against inflammation and cancer development by reducing oxidative stress. Drug-induced liver injury is a common side effect of many medications, with main symptoms ranging from an increase in asymptomatic liver enzymes to liver failure such as acetaminophen (AAP). The main objective of the present work is the protective effect of 5 selenocyantouracil (5SeU) against liver and kidney damage induced by AAP. Fifty male rats were divided into 4 groups consisting: Group A: rats were given only food and distal water (DW). Group B: rats were treated with acetaminophen (500mg/kg). Group C: rats were given acetaminophen in the preceding dose, and 5SeU (50 mg/kg). Group D: rats were treated with acetaminophen orally at the prior dose, and 5SeU (100mg/kg) orally once daily for 21 days. The results revealed significant differences of liver enzymes, urea and creatinine values at 5SeU treated groups in comparison with AAP group. Histopathological examinations confirm such results. As a conclusion, 5SeU compound has a protective activity against AAP-induced tissue damage.
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| first_indexed | 2024-04-24T17:06:13Z |
| format | Article |
| id | doaj.art-7d4fbbc1815b4974bc76e74d36b08cbc |
| institution | Directory Open Access Journal |
| issn | 1683-3597 2521-3512 |
| language | English |
| last_indexed | 2024-04-24T17:06:13Z |
| publishDate | 2024-03-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-7d4fbbc1815b4974bc76e74d36b08cbc2024-03-29T00:23:42ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences1683-35972521-35122024-03-0133110.31351/vol33iss1pp23-32Study The Effects of 5 Selenocyantouracil Compound on The liver and Kidney of Male Rats After Acetaminophen-Induced Liver InjurySahar Muayad Noori0Nadheerah Falih Neamah1Shaker Abdalsalim Al-Jadaan2Department Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Basrah, Iraq.Department Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Basrah, Iraq.Department Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Basrah, Iraq. Selenium compounds have long been assumed to protect organs against inflammation and cancer development by reducing oxidative stress. Drug-induced liver injury is a common side effect of many medications, with main symptoms ranging from an increase in asymptomatic liver enzymes to liver failure such as acetaminophen (AAP). The main objective of the present work is the protective effect of 5 selenocyantouracil (5SeU) against liver and kidney damage induced by AAP. Fifty male rats were divided into 4 groups consisting: Group A: rats were given only food and distal water (DW). Group B: rats were treated with acetaminophen (500mg/kg). Group C: rats were given acetaminophen in the preceding dose, and 5SeU (50 mg/kg). Group D: rats were treated with acetaminophen orally at the prior dose, and 5SeU (100mg/kg) orally once daily for 21 days. The results revealed significant differences of liver enzymes, urea and creatinine values at 5SeU treated groups in comparison with AAP group. Histopathological examinations confirm such results. As a conclusion, 5SeU compound has a protective activity against AAP-induced tissue damage. https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/22635-selenacyanatouracil, Acetaminophen, ALT, AST, Creatinine, Urea, Histopathology |
| spellingShingle | Sahar Muayad Noori Nadheerah Falih Neamah Shaker Abdalsalim Al-Jadaan Study The Effects of 5 Selenocyantouracil Compound on The liver and Kidney of Male Rats After Acetaminophen-Induced Liver Injury Iraqi Journal of Pharmaceutical Sciences 5-selenacyanatouracil, Acetaminophen, ALT, AST, Creatinine, Urea, Histopathology |
| title | Study The Effects of 5 Selenocyantouracil Compound on The liver and Kidney of Male Rats After Acetaminophen-Induced Liver Injury |
| title_full | Study The Effects of 5 Selenocyantouracil Compound on The liver and Kidney of Male Rats After Acetaminophen-Induced Liver Injury |
| title_fullStr | Study The Effects of 5 Selenocyantouracil Compound on The liver and Kidney of Male Rats After Acetaminophen-Induced Liver Injury |
| title_full_unstemmed | Study The Effects of 5 Selenocyantouracil Compound on The liver and Kidney of Male Rats After Acetaminophen-Induced Liver Injury |
| title_short | Study The Effects of 5 Selenocyantouracil Compound on The liver and Kidney of Male Rats After Acetaminophen-Induced Liver Injury |
| title_sort | study the effects of 5 selenocyantouracil compound on the liver and kidney of male rats after acetaminophen induced liver injury |
| topic | 5-selenacyanatouracil, Acetaminophen, ALT, AST, Creatinine, Urea, Histopathology |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2263 |
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