Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion Syndrome
The guidelines for management of children with 22q11.2 deletion syndrome (22q11DS) highlight the risk for developing hypocalcemia after surgery and recommend monitoring calcium perioperatively. Despite this guidance, little has been published on postoperative hypocalcemia and 22q11DS. Our goals were...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/10/1905 |
| _version_ | 1797473142064545792 |
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| author | Jill M. Arganbright Meghan Tracy Max Feldt Srivats Narayanan Ashna Mahadev Janelle Noel-MacDonnell |
| author_facet | Jill M. Arganbright Meghan Tracy Max Feldt Srivats Narayanan Ashna Mahadev Janelle Noel-MacDonnell |
| author_sort | Jill M. Arganbright |
| collection | DOAJ |
| description | The guidelines for management of children with 22q11.2 deletion syndrome (22q11DS) highlight the risk for developing hypocalcemia after surgery and recommend monitoring calcium perioperatively. Despite this guidance, little has been published on postoperative hypocalcemia and 22q11DS. Our goals were to evaluate the frequency of perioperative calcium monitoring and examine how often postoperative hypocalcemia was identified. This is a retrospective chart review of patients in our 22q Center’s repository. Inclusion criteria were a diagnosis of 22q11DS and a history of a non-cardiac surgical procedure. Data collected included all non-cardiac surgeries and perioperative calcium labs. In total, 68 patients were included and underwent 305 on-cardiac surgeries. Patients in only 17% of these surgeries had postoperative calcium testing, but of those tested, 58% showed hypocalcemia. Patients with history of hypocalcemia at the time of chart review undergoing non-cardiac surgeries were tested postoperatively 40% of the time; however, 67% of these had hypocalcemia. Similarly, for patients without history of hypocalcemia, postoperative testing occurred 60% of the time, with 52% of these having hypocalcemia. This study demonstrates that postoperative hypocalcemia in children with 22q11DS following non-cardiac surgeries is common and affects patients both with and without prior history of hypocalcemia. These data support establishing a protocol for perioperative testing/management of hypocalcemia for patients with 22q11DS. |
| first_indexed | 2024-03-09T20:10:45Z |
| format | Article |
| id | doaj.art-7d5082663a134c2aa0f312cd2430ffe8 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T20:10:45Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-7d5082663a134c2aa0f312cd2430ffe82023-11-24T00:17:09ZengMDPI AGGenes2073-44252022-10-011310190510.3390/genes13101905Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion SyndromeJill M. Arganbright0Meghan Tracy1Max Feldt2Srivats Narayanan3Ashna Mahadev4Janelle Noel-MacDonnell5Division of Pediatric Otolaryngology, Children’s Mercy Hospital, Kansas City, MO 64108, USADivision of Pediatric Otolaryngology, Children’s Mercy Hospital, Kansas City, MO 64108, USADivision of Pediatric Endocrinology, Children’s Mercy Hospital, Kansas City, MO 64108, USASchool of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USASchool of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USASchool of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USAThe guidelines for management of children with 22q11.2 deletion syndrome (22q11DS) highlight the risk for developing hypocalcemia after surgery and recommend monitoring calcium perioperatively. Despite this guidance, little has been published on postoperative hypocalcemia and 22q11DS. Our goals were to evaluate the frequency of perioperative calcium monitoring and examine how often postoperative hypocalcemia was identified. This is a retrospective chart review of patients in our 22q Center’s repository. Inclusion criteria were a diagnosis of 22q11DS and a history of a non-cardiac surgical procedure. Data collected included all non-cardiac surgeries and perioperative calcium labs. In total, 68 patients were included and underwent 305 on-cardiac surgeries. Patients in only 17% of these surgeries had postoperative calcium testing, but of those tested, 58% showed hypocalcemia. Patients with history of hypocalcemia at the time of chart review undergoing non-cardiac surgeries were tested postoperatively 40% of the time; however, 67% of these had hypocalcemia. Similarly, for patients without history of hypocalcemia, postoperative testing occurred 60% of the time, with 52% of these having hypocalcemia. This study demonstrates that postoperative hypocalcemia in children with 22q11DS following non-cardiac surgeries is common and affects patients both with and without prior history of hypocalcemia. These data support establishing a protocol for perioperative testing/management of hypocalcemia for patients with 22q11DS.https://www.mdpi.com/2073-4425/13/10/190522q deletion syndromepostoperative hypocalcemiasurgical procedures |
| spellingShingle | Jill M. Arganbright Meghan Tracy Max Feldt Srivats Narayanan Ashna Mahadev Janelle Noel-MacDonnell Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion Syndrome Genes 22q deletion syndrome postoperative hypocalcemia surgical procedures |
| title | Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion Syndrome |
| title_full | Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion Syndrome |
| title_fullStr | Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion Syndrome |
| title_full_unstemmed | Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion Syndrome |
| title_short | Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion Syndrome |
| title_sort | postoperative hypocalcemia following non cardiac surgical procedures in children with 22q11 2 deletion syndrome |
| topic | 22q deletion syndrome postoperative hypocalcemia surgical procedures |
| url | https://www.mdpi.com/2073-4425/13/10/1905 |
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