Innate immune regulation in HIV latency models

Innate immune regulation in HIV latency models

Abstract Background Innate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV infection within CD4 + T cells. Despite these defenses, some acutely infected cells silence viral transcription to become latently infected and form the HIV reservoir in vivo. Latently infe...

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Bibliographic Details
Main Authors: Rebecca M. Olson, Germán Gornalusse, Leanne S. Whitmore, Dan Newhouse, Jennifer Tisoncik-Go, Elise Smith, Christina Ochsenbauer, Florian Hladik, Michael Gale
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Retrovirology
Subjects:
HIV
Latent infection
Reservoir
Innate immunity
Interferon
Interferon-stimulated gene
Online Access:https://doi.org/10.1186/s12977-022-00599-z

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