Tear matrix metalloproteinase-9 levels may help to follow a ocular surface injury in lagophthalmic eyes.
The preocular tear film is critically important for maintaining healthy ocular surface. In lagophthalmos, increased evaporation and tear film instability can occur. The level of tear matrix metalloproteinase 9 (MMP-9) is considered as a possible marker of ocular surface damage and inflammation. The...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0274173 |
| _version_ | 1811203915147902976 |
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| author | Marcela Minaříková Zdeněk Fík Josef Štorm Kateřina Helisová Květoslava Ferrová Gabriela Mahelková |
| author_facet | Marcela Minaříková Zdeněk Fík Josef Štorm Kateřina Helisová Květoslava Ferrová Gabriela Mahelková |
| author_sort | Marcela Minaříková |
| collection | DOAJ |
| description | The preocular tear film is critically important for maintaining healthy ocular surface. In lagophthalmos, increased evaporation and tear film instability can occur. The level of tear matrix metalloproteinase 9 (MMP-9) is considered as a possible marker of ocular surface damage and inflammation. The aim of this study was to evaluate the possible usefulness of measuring tear film levels of MMP-9 in patients with lagophthalmos. Sixteen adult patients with unilateral lagophthalmos due to cerebellopontine angle mass surgery were included. Basic clinical examination including tear film osmolarity, degree of lagophthalmos, ocular surface sensitivity testing, corneal fluorescein staining, and tear break-up time (TBUT) were performed. Furthermore, tear MMP-9 quantification was performed and the values from lagophthalmic and contralateral healthy eye were compared. Possible correlations between tear MMP-9 levels and other parameters were analyzed. The Oxford score was higher in lagophthalmic eyes in comparison to healthy eyes. TBUT and corneal sensitivity were lower in lagophthalmic eyes. There was no difference in osmolarity between the two groups. Tear MMP-9 values were higher in lagophthalmic eyes. A higher MMP-9 value was associated with an increase in ocular surface fluorescein staining and a decrease of TBUT in lagophthalmic eyes. Tear MMP-9 may be used for monitoring ocular surface damage, contribute to early detection of inflammation progression and facilitate treatment adjustments. |
| first_indexed | 2024-04-12T03:04:01Z |
| format | Article |
| id | doaj.art-7d52d57bedb446cebb54f9e6e8f43090 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T03:04:01Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7d52d57bedb446cebb54f9e6e8f430902022-12-22T03:50:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027417310.1371/journal.pone.0274173Tear matrix metalloproteinase-9 levels may help to follow a ocular surface injury in lagophthalmic eyes.Marcela MinaříkováZdeněk FíkJosef ŠtormKateřina HelisováKvětoslava FerrováGabriela MahelkováThe preocular tear film is critically important for maintaining healthy ocular surface. In lagophthalmos, increased evaporation and tear film instability can occur. The level of tear matrix metalloproteinase 9 (MMP-9) is considered as a possible marker of ocular surface damage and inflammation. The aim of this study was to evaluate the possible usefulness of measuring tear film levels of MMP-9 in patients with lagophthalmos. Sixteen adult patients with unilateral lagophthalmos due to cerebellopontine angle mass surgery were included. Basic clinical examination including tear film osmolarity, degree of lagophthalmos, ocular surface sensitivity testing, corneal fluorescein staining, and tear break-up time (TBUT) were performed. Furthermore, tear MMP-9 quantification was performed and the values from lagophthalmic and contralateral healthy eye were compared. Possible correlations between tear MMP-9 levels and other parameters were analyzed. The Oxford score was higher in lagophthalmic eyes in comparison to healthy eyes. TBUT and corneal sensitivity were lower in lagophthalmic eyes. There was no difference in osmolarity between the two groups. Tear MMP-9 values were higher in lagophthalmic eyes. A higher MMP-9 value was associated with an increase in ocular surface fluorescein staining and a decrease of TBUT in lagophthalmic eyes. Tear MMP-9 may be used for monitoring ocular surface damage, contribute to early detection of inflammation progression and facilitate treatment adjustments.https://doi.org/10.1371/journal.pone.0274173 |
| spellingShingle | Marcela Minaříková Zdeněk Fík Josef Štorm Kateřina Helisová Květoslava Ferrová Gabriela Mahelková Tear matrix metalloproteinase-9 levels may help to follow a ocular surface injury in lagophthalmic eyes. PLoS ONE |
| title | Tear matrix metalloproteinase-9 levels may help to follow a ocular surface injury in lagophthalmic eyes. |
| title_full | Tear matrix metalloproteinase-9 levels may help to follow a ocular surface injury in lagophthalmic eyes. |
| title_fullStr | Tear matrix metalloproteinase-9 levels may help to follow a ocular surface injury in lagophthalmic eyes. |
| title_full_unstemmed | Tear matrix metalloproteinase-9 levels may help to follow a ocular surface injury in lagophthalmic eyes. |
| title_short | Tear matrix metalloproteinase-9 levels may help to follow a ocular surface injury in lagophthalmic eyes. |
| title_sort | tear matrix metalloproteinase 9 levels may help to follow a ocular surface injury in lagophthalmic eyes |
| url | https://doi.org/10.1371/journal.pone.0274173 |
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