From bench to bedside – current clinical and translational challenges in fibula free flap reconstruction
Fibula free flaps (FFF) represent a working horse for different reconstructive scenarios in facial surgery. While FFF were initially established for mandible reconstruction, advancements in planning for microsurgical techniques have paved the way toward a broader spectrum of indications, including m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1246690/full |
| _version_ | 1797662133624766464 |
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| author | Helena Baecher Cosima C. Hoch Samuel Knoedler Samuel Knoedler Samuel Knoedler Bhagvat J. Maheta Martin Kauke-Navarro Ali-Farid Safi Ali-Farid Safi Michael Alfertshofer Leonard Knoedler Leonard Knoedler |
| author_facet | Helena Baecher Cosima C. Hoch Samuel Knoedler Samuel Knoedler Samuel Knoedler Bhagvat J. Maheta Martin Kauke-Navarro Ali-Farid Safi Ali-Farid Safi Michael Alfertshofer Leonard Knoedler Leonard Knoedler |
| author_sort | Helena Baecher |
| collection | DOAJ |
| description | Fibula free flaps (FFF) represent a working horse for different reconstructive scenarios in facial surgery. While FFF were initially established for mandible reconstruction, advancements in planning for microsurgical techniques have paved the way toward a broader spectrum of indications, including maxillary defects. Essential factors to improve patient outcomes following FFF include minimal donor site morbidity, adequate bone length, and dual blood supply. Yet, persisting clinical and translational challenges hamper the effectiveness of FFF. In the preoperative phase, virtual surgical planning and artificial intelligence tools carry untapped potential, while the intraoperative role of individualized surgical templates and bioprinted prostheses remains to be summarized. Further, the integration of novel flap monitoring technologies into postoperative patient management has been subject to translational and clinical research efforts. Overall, there is a paucity of studies condensing the body of knowledge on emerging technologies and techniques in FFF surgery. Herein, we aim to review current challenges and solution possibilities in FFF. This line of research may serve as a pocket guide on cutting-edge developments and facilitate future targeted research in FFF. |
| first_indexed | 2024-03-11T18:54:41Z |
| format | Article |
| id | doaj.art-7d5321ca1e294abe91ca1aee77604148 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-11T18:54:41Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-7d5321ca1e294abe91ca1aee776041482023-10-11T05:59:16ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-10-011010.3389/fmed.2023.12466901246690From bench to bedside – current clinical and translational challenges in fibula free flap reconstructionHelena Baecher0Cosima C. Hoch1Samuel Knoedler2Samuel Knoedler3Samuel Knoedler4Bhagvat J. Maheta5Martin Kauke-Navarro6Ali-Farid Safi7Ali-Farid Safi8Michael Alfertshofer9Leonard Knoedler10Leonard Knoedler11Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, GermanyMedical Faculty, Friedrich Schiller University Jena, Jena, GermanyDivision of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United StatesDivision of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Plastic Surgery and Hand Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, GermanyCollege of Medicine, California Northstate University, Elk Grove, CA, United StatesDivision of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United StatesCraniologicum, Center for Cranio-Maxillo-Facial Surgery, Bern, SwitzerlandFaculty of Medicine, University of Bern, Bern, SwitzerlandDivision of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University Munich, Munich, GermanyDepartment of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, GermanyDivision of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United StatesFibula free flaps (FFF) represent a working horse for different reconstructive scenarios in facial surgery. While FFF were initially established for mandible reconstruction, advancements in planning for microsurgical techniques have paved the way toward a broader spectrum of indications, including maxillary defects. Essential factors to improve patient outcomes following FFF include minimal donor site morbidity, adequate bone length, and dual blood supply. Yet, persisting clinical and translational challenges hamper the effectiveness of FFF. In the preoperative phase, virtual surgical planning and artificial intelligence tools carry untapped potential, while the intraoperative role of individualized surgical templates and bioprinted prostheses remains to be summarized. Further, the integration of novel flap monitoring technologies into postoperative patient management has been subject to translational and clinical research efforts. Overall, there is a paucity of studies condensing the body of knowledge on emerging technologies and techniques in FFF surgery. Herein, we aim to review current challenges and solution possibilities in FFF. This line of research may serve as a pocket guide on cutting-edge developments and facilitate future targeted research in FFF.https://www.frontiersin.org/articles/10.3389/fmed.2023.1246690/fullfibula free flapmandibular reconstructionartificial intelligence3D printingcomputer-aided designCAM |
| spellingShingle | Helena Baecher Cosima C. Hoch Samuel Knoedler Samuel Knoedler Samuel Knoedler Bhagvat J. Maheta Martin Kauke-Navarro Ali-Farid Safi Ali-Farid Safi Michael Alfertshofer Leonard Knoedler Leonard Knoedler From bench to bedside – current clinical and translational challenges in fibula free flap reconstruction Frontiers in Medicine fibula free flap mandibular reconstruction artificial intelligence 3D printing computer-aided design CAM |
| title | From bench to bedside – current clinical and translational challenges in fibula free flap reconstruction |
| title_full | From bench to bedside – current clinical and translational challenges in fibula free flap reconstruction |
| title_fullStr | From bench to bedside – current clinical and translational challenges in fibula free flap reconstruction |
| title_full_unstemmed | From bench to bedside – current clinical and translational challenges in fibula free flap reconstruction |
| title_short | From bench to bedside – current clinical and translational challenges in fibula free flap reconstruction |
| title_sort | from bench to bedside current clinical and translational challenges in fibula free flap reconstruction |
| topic | fibula free flap mandibular reconstruction artificial intelligence 3D printing computer-aided design CAM |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1246690/full |
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