Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy In Vivo

Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy In Vivo

ABSTRACT Every year, dengue virus (DENV) causes one hundred million infections worldwide that can result in dengue disease and severe dengue. Two other mosquito-borne flaviviruses, i.e., Zika virus (ZIKV) and West Nile virus (WNV), are responsible of prolonged outbreaks and are associated with sever...

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Bibliographic Details
Main Authors: Marta Celegato, Mattia Sturlese, Vivian Vasconcelos Costa, Marta Trevisan, Angélica Samer Lallo Dias, Ingredy Beatriz Souza Passos, Celso Martins Queiroz-Junior, Lorenzo Messa, Annagiulia Favaro, Stefano Moro, Mauro Martins Teixeira, Arianna Loregian, Beatrice Mercorelli
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
flavivirus
NS3-NS5 interaction
dissociative inhibitors
antiviral drugs
dengue virus
West-Nile virus
Online Access:https://journals.asm.org/doi/10.1128/mbio.03097-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03097-22

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