Shared Pathogenic and Therapeutic Characteristics of Endometriosis, Adenomyosis, and Endometrial Cancer: A Comprehensive Literature Review
Endometriosis and adenomyosis behave similarly to cancer. No current treatments represent a cure, even if there are several options, including hormonal and surgical therapy. In advanced or recurrent pathologies, however, personalized treatment is necessary. We have found that due to the multiple com...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/17/3/311 |
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| author | Melinda-Ildiko Mitranovici Diana Maria Chiorean Liviu Moraru Raluca Moraru Laura Caravia Andreea Taisia Tiron Titiana Cornelia Cotoi Havva Serap Toru Ovidiu Simion Cotoi |
| author_facet | Melinda-Ildiko Mitranovici Diana Maria Chiorean Liviu Moraru Raluca Moraru Laura Caravia Andreea Taisia Tiron Titiana Cornelia Cotoi Havva Serap Toru Ovidiu Simion Cotoi |
| author_sort | Melinda-Ildiko Mitranovici |
| collection | DOAJ |
| description | Endometriosis and adenomyosis behave similarly to cancer. No current treatments represent a cure, even if there are several options, including hormonal and surgical therapy. In advanced or recurrent pathologies, however, personalized treatment is necessary. We have found that due to the multiple common features, various therapeutic options have been used or studied for all three pathologies, with varying results. The objective of this review is to extract from the relevant literature the compounds that are used for endometriosis and adenomyosis characterized by malignant behavior, with some of these drugs being studied first in the treatment of endometrial cancer. Special attention is needed in the pathogenesis of these pathologies. Despite the multiple drugs that have been tested, only a few of them have been introduced into clinical practice. An unmet need is the cure of these diseases. Long-time treatment is necessary because symptoms persist, and surgery is often followed by postoperative recurrence. We emphasize the need for new, effective, long-term treatments based on pathogeny while considering their adverse effects. |
| first_indexed | 2024-04-24T17:56:10Z |
| format | Article |
| id | doaj.art-7d5523da320c45bab74263b0b568cfb9 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-04-24T17:56:10Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-7d5523da320c45bab74263b0b568cfb92024-03-27T13:59:15ZengMDPI AGPharmaceuticals1424-82472024-02-0117331110.3390/ph17030311Shared Pathogenic and Therapeutic Characteristics of Endometriosis, Adenomyosis, and Endometrial Cancer: A Comprehensive Literature ReviewMelinda-Ildiko Mitranovici0Diana Maria Chiorean1Liviu Moraru2Raluca Moraru3Laura Caravia4Andreea Taisia Tiron5Titiana Cornelia Cotoi6Havva Serap Toru7Ovidiu Simion Cotoi8Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, RomaniaDepartment of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, RomaniaDepartment of Anatomy, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, RomaniaFaculty of Medicine, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, RomaniaDivision of Cellular and Molecular Biology and Histology, Department of Morphological Sciences, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Pharmaceutical Technology, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, RomaniaDepartment of Pathology, Akdeniz University School of Medicine, Antalya Pınarbaşı, Konyaaltı, Antalya 07070, TurkeyDepartment of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, RomaniaEndometriosis and adenomyosis behave similarly to cancer. No current treatments represent a cure, even if there are several options, including hormonal and surgical therapy. In advanced or recurrent pathologies, however, personalized treatment is necessary. We have found that due to the multiple common features, various therapeutic options have been used or studied for all three pathologies, with varying results. The objective of this review is to extract from the relevant literature the compounds that are used for endometriosis and adenomyosis characterized by malignant behavior, with some of these drugs being studied first in the treatment of endometrial cancer. Special attention is needed in the pathogenesis of these pathologies. Despite the multiple drugs that have been tested, only a few of them have been introduced into clinical practice. An unmet need is the cure of these diseases. Long-time treatment is necessary because symptoms persist, and surgery is often followed by postoperative recurrence. We emphasize the need for new, effective, long-term treatments based on pathogeny while considering their adverse effects.https://www.mdpi.com/1424-8247/17/3/311endometriosisadenomyosispathogenesisendometrial cancermalignant behaviorpersonalized treatments |
| spellingShingle | Melinda-Ildiko Mitranovici Diana Maria Chiorean Liviu Moraru Raluca Moraru Laura Caravia Andreea Taisia Tiron Titiana Cornelia Cotoi Havva Serap Toru Ovidiu Simion Cotoi Shared Pathogenic and Therapeutic Characteristics of Endometriosis, Adenomyosis, and Endometrial Cancer: A Comprehensive Literature Review Pharmaceuticals endometriosis adenomyosis pathogenesis endometrial cancer malignant behavior personalized treatments |
| title | Shared Pathogenic and Therapeutic Characteristics of Endometriosis, Adenomyosis, and Endometrial Cancer: A Comprehensive Literature Review |
| title_full | Shared Pathogenic and Therapeutic Characteristics of Endometriosis, Adenomyosis, and Endometrial Cancer: A Comprehensive Literature Review |
| title_fullStr | Shared Pathogenic and Therapeutic Characteristics of Endometriosis, Adenomyosis, and Endometrial Cancer: A Comprehensive Literature Review |
| title_full_unstemmed | Shared Pathogenic and Therapeutic Characteristics of Endometriosis, Adenomyosis, and Endometrial Cancer: A Comprehensive Literature Review |
| title_short | Shared Pathogenic and Therapeutic Characteristics of Endometriosis, Adenomyosis, and Endometrial Cancer: A Comprehensive Literature Review |
| title_sort | shared pathogenic and therapeutic characteristics of endometriosis adenomyosis and endometrial cancer a comprehensive literature review |
| topic | endometriosis adenomyosis pathogenesis endometrial cancer malignant behavior personalized treatments |
| url | https://www.mdpi.com/1424-8247/17/3/311 |
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