Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia

Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia

The transcription factor Krueppel-like factor (KLF) 4 fosters the pro-inflammatory immune response in macrophages and polymorphonuclear neutrophils (PMNs) when stimulated with Streptococcus pneumoniae, the main causative pathogen of community-acquired pneumonia (CAP). Here, we investigated the impac...

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Bibliographic Details
Main Authors: Toni Herta, Aritra Bhattacharyya, Maciej Rosolowski, Claudia Conrad, Corinne Gurtner, Achim D. Gruber, Peter Ahnert, Birgitt Gutbier, Doris Frey, Norbert Suttorp, Stefan Hippenstiel, Janine Zahlten
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
Krueppel-like factor 4
Streptococcus pneumoniae
community-acquired pneumonia
innate immunity
myeloid cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.726135/full

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