RIG-I enhanced interferon independent apoptosis upon Junin virus infection.
Junin virus (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF), a human disease with a high case-fatality rate. It is widely accepted that arenaviral infections, including JUNV infections, are generally non-cytopathic. In contrast, here we demonstrated apoptosis induction in human...
Main Authors: | Olga A Kolokoltsova, Ashley M Grant, Cheng Huang, Jennifer K Smith, Allison L Poussard, Bing Tian, Allan R Brasier, Clarence J Peters, Chien-Te Kent Tseng, Juan C de la Torre, Slobodan Paessler |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4053358?pdf=render |
Similar Items
-
Junín Virus Pathogenesis and Virus Replication
by: Olga Kolokoltsova, et al.
Published: (2012-10-01) -
Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner.
by: Cheng Huang, et al.
Published: (2012-01-01) -
A single mutation (V64G) within the RING Domain of Z attenuates Junin virus.
by: Steven J Hallam, et al.
Published: (2020-09-01) -
Junin Virus Activates p38 MAPK and HSP27 Upon Entry
by: Collin J. Fitzpatrick, et al.
Published: (2022-04-01) -
Type I interferon underlies severe disease associated with Junín virus infection in mice
by: Brady T Hickerson, et al.
Published: (2020-05-01)