Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development
Early life adversity (ELA) is associated with increased risk for stress-related disorders later in life. The link between ELA and risk for psychopathology is well established but the developmental mechanisms remain unclear. Using a mouse model of resource insecurity, limited bedding (LB), we tested...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-07-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/55263 |
| _version_ | 1811201333365047296 |
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| author | Gabriela Manzano Nieves Marilyn Bravo Saba Baskoylu Kevin G Bath |
| author_facet | Gabriela Manzano Nieves Marilyn Bravo Saba Baskoylu Kevin G Bath |
| author_sort | Gabriela Manzano Nieves |
| collection | DOAJ |
| description | Early life adversity (ELA) is associated with increased risk for stress-related disorders later in life. The link between ELA and risk for psychopathology is well established but the developmental mechanisms remain unclear. Using a mouse model of resource insecurity, limited bedding (LB), we tested the effects of LB on the development of fear learning and neuronal structures involved in emotional regulation, the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA). LB delayed the ability of peri-weanling (21 days old) mice to express, but not form, an auditory conditioned fear memory. LB accelerated the developmental emergence of parvalbumin (PV)-positive cells in the BLA and increased anatomical connections between PL and BLA. Fear expression in LB mice was rescued through optogenetic inactivation of PV-positive cells in the BLA. The current results provide a model of transiently blunted emotional reactivity in early development, with latent fear-associated memories emerging later in adolescence. |
| first_indexed | 2024-04-12T02:20:02Z |
| format | Article |
| id | doaj.art-7d5748ef541e4f598dafdf5e2d413eea |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:20:02Z |
| publishDate | 2020-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-7d5748ef541e4f598dafdf5e2d413eea2022-12-22T03:52:09ZengeLife Sciences Publications LtdeLife2050-084X2020-07-01910.7554/eLife.55263Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell developmentGabriela Manzano Nieves0https://orcid.org/0000-0001-6989-4872Marilyn Bravo1Saba Baskoylu2Kevin G Bath3https://orcid.org/0000-0003-2229-177XDepartment of Neuroscience, Brown University, Providence, United StatesDepartment of Neuroscience, Brown University, Providence, United StatesDepartment of Neuroscience, Brown University, Providence, United StatesDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, United StatesEarly life adversity (ELA) is associated with increased risk for stress-related disorders later in life. The link between ELA and risk for psychopathology is well established but the developmental mechanisms remain unclear. Using a mouse model of resource insecurity, limited bedding (LB), we tested the effects of LB on the development of fear learning and neuronal structures involved in emotional regulation, the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA). LB delayed the ability of peri-weanling (21 days old) mice to express, but not form, an auditory conditioned fear memory. LB accelerated the developmental emergence of parvalbumin (PV)-positive cells in the BLA and increased anatomical connections between PL and BLA. Fear expression in LB mice was rescued through optogenetic inactivation of PV-positive cells in the BLA. The current results provide a model of transiently blunted emotional reactivity in early development, with latent fear-associated memories emerging later in adolescence.https://elifesciences.org/articles/55263mouseearly life adversitymedial prefrontal cortexamygdaladevelopmentfear conditioning |
| spellingShingle | Gabriela Manzano Nieves Marilyn Bravo Saba Baskoylu Kevin G Bath Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development eLife mouse early life adversity medial prefrontal cortex amygdala development fear conditioning |
| title | Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development |
| title_full | Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development |
| title_fullStr | Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development |
| title_full_unstemmed | Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development |
| title_short | Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development |
| title_sort | early life adversity decreases pre adolescent fear expression by accelerating amygdala pv cell development |
| topic | mouse early life adversity medial prefrontal cortex amygdala development fear conditioning |
| url | https://elifesciences.org/articles/55263 |
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