Targeting Mitochondrial Dysfunction in Lung Diseases: Emphasis on Mitophagy
During mild stressful conditions, cells activate a multitude of mechanisms in an attempt to repair or re-establish homeostasis. One such mechanism is autophagic degradation of mitochondria or mitophagy to dispose damaged mitochondria. However, if stress persists beyond recovery then dysfunctional mi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00384/full |
| _version_ | 1811326268631678976 |
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| author | Sureshbabu eAngara Vineet eBhandari |
| author_facet | Sureshbabu eAngara Vineet eBhandari |
| author_sort | Sureshbabu eAngara |
| collection | DOAJ |
| description | During mild stressful conditions, cells activate a multitude of mechanisms in an attempt to repair or re-establish homeostasis. One such mechanism is autophagic degradation of mitochondria or mitophagy to dispose damaged mitochondria. However, if stress persists beyond recovery then dysfunctional mitochondria can ignite cell death. This review article summarizes recent studies highlighting the molecular pathways that facilitate mitochondria to alter its morphological dynamics, coordinate stress responses, initiate mitophagy and activate cell death in relevance to pulmonary pathologies. Thorough understanding of how these signaling mechanisms get disrupted may aid in designing new mitochondria-based therapies to combat lung diseases. |
| first_indexed | 2024-04-13T14:47:06Z |
| format | Article |
| id | doaj.art-7d574deb10664294b14249090f53e7cb |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T14:47:06Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-7d574deb10664294b14249090f53e7cb2022-12-22T02:42:43ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2013-12-01410.3389/fphys.2013.0038473037Targeting Mitochondrial Dysfunction in Lung Diseases: Emphasis on MitophagySureshbabu eAngara0Vineet eBhandari1Yale University School of MedicineYale University School of MedicineDuring mild stressful conditions, cells activate a multitude of mechanisms in an attempt to repair or re-establish homeostasis. One such mechanism is autophagic degradation of mitochondria or mitophagy to dispose damaged mitochondria. However, if stress persists beyond recovery then dysfunctional mitochondria can ignite cell death. This review article summarizes recent studies highlighting the molecular pathways that facilitate mitochondria to alter its morphological dynamics, coordinate stress responses, initiate mitophagy and activate cell death in relevance to pulmonary pathologies. Thorough understanding of how these signaling mechanisms get disrupted may aid in designing new mitochondria-based therapies to combat lung diseases.http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00384/fullApoptosisMitochondriaReactive Oxygen Speciesmitophagypulmonary disease |
| spellingShingle | Sureshbabu eAngara Vineet eBhandari Targeting Mitochondrial Dysfunction in Lung Diseases: Emphasis on Mitophagy Frontiers in Physiology Apoptosis Mitochondria Reactive Oxygen Species mitophagy pulmonary disease |
| title | Targeting Mitochondrial Dysfunction in Lung Diseases: Emphasis on Mitophagy |
| title_full | Targeting Mitochondrial Dysfunction in Lung Diseases: Emphasis on Mitophagy |
| title_fullStr | Targeting Mitochondrial Dysfunction in Lung Diseases: Emphasis on Mitophagy |
| title_full_unstemmed | Targeting Mitochondrial Dysfunction in Lung Diseases: Emphasis on Mitophagy |
| title_short | Targeting Mitochondrial Dysfunction in Lung Diseases: Emphasis on Mitophagy |
| title_sort | targeting mitochondrial dysfunction in lung diseases emphasis on mitophagy |
| topic | Apoptosis Mitochondria Reactive Oxygen Species mitophagy pulmonary disease |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00384/full |
| work_keys_str_mv | AT sureshbabueangara targetingmitochondrialdysfunctioninlungdiseasesemphasisonmitophagy AT vineetebhandari targetingmitochondrialdysfunctioninlungdiseasesemphasisonmitophagy |