QuantiFERON-TB Gold PLUS versus QuantiFERON-TB Gold In-Tube test for diagnosing tuberculosis infection
Background/Aims QuantiFERON-TB Gold PLUS (QFT-PLUS) was developed as a new version of the interferon-γ (IFN-γ) release assay that contains an extra antigen tube to elicit a CD8+ T-cell response in addition to a CD4+ T-cell response. This study aimed to evaluate the performances of QFT-PLUS versus Qu...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2020-03-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/pdf/kjim-2019-002.pdf |
| _version_ | 1819112472535105536 |
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| author | Soo Han Kim Kyung-Wook Jo Tae Sun Shim |
| author_facet | Soo Han Kim Kyung-Wook Jo Tae Sun Shim |
| author_sort | Soo Han Kim |
| collection | DOAJ |
| description | Background/Aims QuantiFERON-TB Gold PLUS (QFT-PLUS) was developed as a new version of the interferon-γ (IFN-γ) release assay that contains an extra antigen tube to elicit a CD8+ T-cell response in addition to a CD4+ T-cell response. This study aimed to evaluate the performances of QFT-PLUS versus QuantiFERON-TB Gold In-Tube (QFT-GIT) for detecting tuberculosis (TB) infection. Methods Between October, 2016 and May, 2018, 137 participants were prospectively recruited and subjected to QFT-GIT and QFT-PLUS testing. The concordance between tests and performance based on different immune states and/or TB infection risk were evaluated. Results The 137 participants were classified as follows: active TB (n = 14), TB contact (n = 14), screening before biologic therapy (n = 85) and other disease (n = 24). The positive results for either test were 100% (n = 14/14), 42.9% (n = 6/14), 15.3% (n = 13/85), and 62.5% (n = 15/24) in each four groups, respectively. The QFT-GIT and QFT-PLUS test results showed good concordance with 91.2% agreement and a Cohen’s κ of 0.807. The good concordance between two tests was also observed in 64 immunocompromised subjects (agreement of 90.6% and a Cohen’s κ of 0.711). The intra-class correlation coefficient for each antigen tube of the QFT-PLUS showed a good correlation with the IFN-γ release of the QFT-GIT (TB1 = 0.912, p < 0.001; TB2 = 0.918, p < 0.001). Conclusions QFT-PLUS showed highly comparable results to those of QFT-GIT for diagnosing TB infection in South Korea as well as in immunocompromised subjects. |
| first_indexed | 2024-12-22T04:14:03Z |
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| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-22T04:14:03Z |
| publishDate | 2020-03-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-7d5a47ced1994066a13e4e0e24846df22022-12-21T18:39:28ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-03-0135238339110.3904/kjim.2019.002170281QuantiFERON-TB Gold PLUS versus QuantiFERON-TB Gold In-Tube test for diagnosing tuberculosis infectionSoo Han Kim0Kyung-Wook Jo1Tae Sun Shim2 Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground/Aims QuantiFERON-TB Gold PLUS (QFT-PLUS) was developed as a new version of the interferon-γ (IFN-γ) release assay that contains an extra antigen tube to elicit a CD8+ T-cell response in addition to a CD4+ T-cell response. This study aimed to evaluate the performances of QFT-PLUS versus QuantiFERON-TB Gold In-Tube (QFT-GIT) for detecting tuberculosis (TB) infection. Methods Between October, 2016 and May, 2018, 137 participants were prospectively recruited and subjected to QFT-GIT and QFT-PLUS testing. The concordance between tests and performance based on different immune states and/or TB infection risk were evaluated. Results The 137 participants were classified as follows: active TB (n = 14), TB contact (n = 14), screening before biologic therapy (n = 85) and other disease (n = 24). The positive results for either test were 100% (n = 14/14), 42.9% (n = 6/14), 15.3% (n = 13/85), and 62.5% (n = 15/24) in each four groups, respectively. The QFT-GIT and QFT-PLUS test results showed good concordance with 91.2% agreement and a Cohen’s κ of 0.807. The good concordance between two tests was also observed in 64 immunocompromised subjects (agreement of 90.6% and a Cohen’s κ of 0.711). The intra-class correlation coefficient for each antigen tube of the QFT-PLUS showed a good correlation with the IFN-γ release of the QFT-GIT (TB1 = 0.912, p < 0.001; TB2 = 0.918, p < 0.001). Conclusions QFT-PLUS showed highly comparable results to those of QFT-GIT for diagnosing TB infection in South Korea as well as in immunocompromised subjects.http://www.kjim.org/upload/pdf/kjim-2019-002.pdflatent tuberculosisinterferon-gamma release testscd8-positive t-lymphocyte |
| spellingShingle | Soo Han Kim Kyung-Wook Jo Tae Sun Shim QuantiFERON-TB Gold PLUS versus QuantiFERON-TB Gold In-Tube test for diagnosing tuberculosis infection The Korean Journal of Internal Medicine latent tuberculosis interferon-gamma release tests cd8-positive t-lymphocyte |
| title | QuantiFERON-TB Gold PLUS versus QuantiFERON-TB Gold In-Tube test for diagnosing tuberculosis infection |
| title_full | QuantiFERON-TB Gold PLUS versus QuantiFERON-TB Gold In-Tube test for diagnosing tuberculosis infection |
| title_fullStr | QuantiFERON-TB Gold PLUS versus QuantiFERON-TB Gold In-Tube test for diagnosing tuberculosis infection |
| title_full_unstemmed | QuantiFERON-TB Gold PLUS versus QuantiFERON-TB Gold In-Tube test for diagnosing tuberculosis infection |
| title_short | QuantiFERON-TB Gold PLUS versus QuantiFERON-TB Gold In-Tube test for diagnosing tuberculosis infection |
| title_sort | quantiferon tb gold plus versus quantiferon tb gold in tube test for diagnosing tuberculosis infection |
| topic | latent tuberculosis interferon-gamma release tests cd8-positive t-lymphocyte |
| url | http://www.kjim.org/upload/pdf/kjim-2019-002.pdf |
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