Autophagy in intestinal fibrosis: relevance in inflammatory bowel disease
Chronic inflammation is often associated with fibrotic disorders in which an excessive deposition of extracellular matrix is a hallmark. Long-term fibrosis starts with tissue hypofunction and finally ends in organ failure. Intestinal fibrosis is not an exception, and it is a frequent complication of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1170436/full |
| _version_ | 1827925887848284160 |
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| author | Dulce C. Macias-Ceja María D. Barrachina Dolores Ortiz-Masià Dolores Ortiz-Masià |
| author_facet | Dulce C. Macias-Ceja María D. Barrachina Dolores Ortiz-Masià Dolores Ortiz-Masià |
| author_sort | Dulce C. Macias-Ceja |
| collection | DOAJ |
| description | Chronic inflammation is often associated with fibrotic disorders in which an excessive deposition of extracellular matrix is a hallmark. Long-term fibrosis starts with tissue hypofunction and finally ends in organ failure. Intestinal fibrosis is not an exception, and it is a frequent complication of inflammatory bowel disease (IBD). Several studies have confirmed the link between deregulated autophagy and fibrosis and the presence of common prognostic markers; indeed, both up- and downregulation of autophagy are presumed to be implicated in the progression of fibrosis. A better knowledge of the role of autophagy in fibrosis may lead to it becoming a potential target of antifibrotic therapy. In this review we explore novel advances in the field that highlight the relevance of autophagy in fibrosis, and give special focus to fibrosis in IBD patients. |
| first_indexed | 2024-03-13T05:30:32Z |
| format | Article |
| id | doaj.art-7d5d4085e1884421bfd0045db0817cf4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-13T05:30:32Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7d5d4085e1884421bfd0045db0817cf42023-06-15T04:39:04ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-06-011410.3389/fphar.2023.11704361170436Autophagy in intestinal fibrosis: relevance in inflammatory bowel diseaseDulce C. Macias-Ceja0María D. Barrachina1Dolores Ortiz-Masià2Dolores Ortiz-Masià3Departamento de Farmacología and CIBER, Facultad de Medicina y Odontología, Universitat de Valencia, Valencia, SpainDepartamento de Farmacología and CIBER, Facultad de Medicina y Odontología, Universitat de Valencia, Valencia, SpainDepartamento de Farmacología and CIBER, Facultad de Medicina y Odontología, Universitat de Valencia, Valencia, SpainDepartamento de Medicina, Facultad de Medicina y Odontología, Universitat de Valencia, Valencia, SpainChronic inflammation is often associated with fibrotic disorders in which an excessive deposition of extracellular matrix is a hallmark. Long-term fibrosis starts with tissue hypofunction and finally ends in organ failure. Intestinal fibrosis is not an exception, and it is a frequent complication of inflammatory bowel disease (IBD). Several studies have confirmed the link between deregulated autophagy and fibrosis and the presence of common prognostic markers; indeed, both up- and downregulation of autophagy are presumed to be implicated in the progression of fibrosis. A better knowledge of the role of autophagy in fibrosis may lead to it becoming a potential target of antifibrotic therapy. In this review we explore novel advances in the field that highlight the relevance of autophagy in fibrosis, and give special focus to fibrosis in IBD patients.https://www.frontiersin.org/articles/10.3389/fphar.2023.1170436/fullfibrosisautophagyintestinal fibrosisinflammatory bowel diseasecolitisCrohn’s disease |
| spellingShingle | Dulce C. Macias-Ceja María D. Barrachina Dolores Ortiz-Masià Dolores Ortiz-Masià Autophagy in intestinal fibrosis: relevance in inflammatory bowel disease Frontiers in Pharmacology fibrosis autophagy intestinal fibrosis inflammatory bowel disease colitis Crohn’s disease |
| title | Autophagy in intestinal fibrosis: relevance in inflammatory bowel disease |
| title_full | Autophagy in intestinal fibrosis: relevance in inflammatory bowel disease |
| title_fullStr | Autophagy in intestinal fibrosis: relevance in inflammatory bowel disease |
| title_full_unstemmed | Autophagy in intestinal fibrosis: relevance in inflammatory bowel disease |
| title_short | Autophagy in intestinal fibrosis: relevance in inflammatory bowel disease |
| title_sort | autophagy in intestinal fibrosis relevance in inflammatory bowel disease |
| topic | fibrosis autophagy intestinal fibrosis inflammatory bowel disease colitis Crohn’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1170436/full |
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