Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors
<p>Abstract</p> <p>Background</p> <p>Brain metastases (BM) from hepatocellular carcinoma (HCC) are extremely rare and are associated with a poor prognosis. The aim of this study was to define clinical outcome and prognostic determinants in patients with BM from HCC.<...
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BMC
2012-02-01
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| Series: | BMC Cancer |
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| Online Access: | http://www.biomedcentral.com/1471-2407/12/49 |
| _version_ | 1818640521217703936 |
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| author | Jiang Xiao-Bing Ke Chao Zhang Guan-Hua Zhang Xiang-Heng Sai Ke Chen Zhong-Ping Mou Yong-Gao |
| author_facet | Jiang Xiao-Bing Ke Chao Zhang Guan-Hua Zhang Xiang-Heng Sai Ke Chen Zhong-Ping Mou Yong-Gao |
| author_sort | Jiang Xiao-Bing |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Brain metastases (BM) from hepatocellular carcinoma (HCC) are extremely rare and are associated with a poor prognosis. The aim of this study was to define clinical outcome and prognostic determinants in patients with BM from HCC.</p> <p>Methods</p> <p>Between January 1994 and December 2009, all patients with HCC and BM treated in Sun Yat-sen University Cancer Center were retrospectively reviewed. Univariate and multivariate survival analyses were performed to identify possible prognostic factors.</p> <p>Results</p> <p>Forty-one patients were diagnosed with BM from HCC, an incidence of 0.47%. The median age at diagnosis of BM was 48.5 years. Thirty-three patients (80.5%) developed extracranial metastases at diagnosis of BM, and 30 patients (73.2%) had hepatitis B. Intracranial hemorrhage occurred in 19 patients (46.3%). BM were treated primarily either with whole brain radiation therapy (WBRT; 5 patients), stereotactic radiosurgery (SRS; 7 patients), or surgical resection (6 patients). The cause of death was systemic disease in 17 patients and neurological disease in 23. Patients in a high RPA (recursive partitioning analysis) class, treated with conservatively and without lung metastases, tended to die from neurological disease. Median survival after the diagnosis of BM was 3 months (95% confidence interval: 2.2-3.8 months). In multivariate analysis, the presence of extracranial metastases, a low RPA class and aggressive treatment, were positively associated with improved survival.</p> <p>Conclusions</p> <p>BM from HCC is rare and associated with an extremely poor prognosis. However, patients with a low RPA class may benefit from aggressive treatment. The clinical implication of extracranial metastases in HCC patients with BM needs further assessment.</p> |
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| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-16T23:12:35Z |
| publishDate | 2012-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-7d5dd0a4cef04c3eb714a47be9be26f12022-12-21T22:12:24ZengBMCBMC Cancer1471-24072012-02-011214910.1186/1471-2407-12-49Brain metastases from hepatocellular carcinoma: clinical features and prognostic factorsJiang Xiao-BingKe ChaoZhang Guan-HuaZhang Xiang-HengSai KeChen Zhong-PingMou Yong-Gao<p>Abstract</p> <p>Background</p> <p>Brain metastases (BM) from hepatocellular carcinoma (HCC) are extremely rare and are associated with a poor prognosis. The aim of this study was to define clinical outcome and prognostic determinants in patients with BM from HCC.</p> <p>Methods</p> <p>Between January 1994 and December 2009, all patients with HCC and BM treated in Sun Yat-sen University Cancer Center were retrospectively reviewed. Univariate and multivariate survival analyses were performed to identify possible prognostic factors.</p> <p>Results</p> <p>Forty-one patients were diagnosed with BM from HCC, an incidence of 0.47%. The median age at diagnosis of BM was 48.5 years. Thirty-three patients (80.5%) developed extracranial metastases at diagnosis of BM, and 30 patients (73.2%) had hepatitis B. Intracranial hemorrhage occurred in 19 patients (46.3%). BM were treated primarily either with whole brain radiation therapy (WBRT; 5 patients), stereotactic radiosurgery (SRS; 7 patients), or surgical resection (6 patients). The cause of death was systemic disease in 17 patients and neurological disease in 23. Patients in a high RPA (recursive partitioning analysis) class, treated with conservatively and without lung metastases, tended to die from neurological disease. Median survival after the diagnosis of BM was 3 months (95% confidence interval: 2.2-3.8 months). In multivariate analysis, the presence of extracranial metastases, a low RPA class and aggressive treatment, were positively associated with improved survival.</p> <p>Conclusions</p> <p>BM from HCC is rare and associated with an extremely poor prognosis. However, patients with a low RPA class may benefit from aggressive treatment. The clinical implication of extracranial metastases in HCC patients with BM needs further assessment.</p>http://www.biomedcentral.com/1471-2407/12/49Brain metastasisHepatocellular carcinomaPrognosisChinese |
| spellingShingle | Jiang Xiao-Bing Ke Chao Zhang Guan-Hua Zhang Xiang-Heng Sai Ke Chen Zhong-Ping Mou Yong-Gao Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors BMC Cancer Brain metastasis Hepatocellular carcinoma Prognosis Chinese |
| title | Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors |
| title_full | Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors |
| title_fullStr | Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors |
| title_full_unstemmed | Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors |
| title_short | Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors |
| title_sort | brain metastases from hepatocellular carcinoma clinical features and prognostic factors |
| topic | Brain metastasis Hepatocellular carcinoma Prognosis Chinese |
| url | http://www.biomedcentral.com/1471-2407/12/49 |
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