Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis
Polydimethylsiloxane (PDMS) is a biocompatible polymer that has been applied in many fields. However, the surface hydrophobicity of PDMS can limit successful implementation, and this must be reduced by surface modification to improve biocompatibility. In this study, we modified the PDMS surface with...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/2/269 |
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| author | Haejin Joo Jonghyun Park Chanutchamon Sutthiwanjampa Hankoo Kim Taehui Bae Wooseob Kim Jinhwa Choi Mikyung Kim Shinhyuk Kang Hansoo Park |
| author_facet | Haejin Joo Jonghyun Park Chanutchamon Sutthiwanjampa Hankoo Kim Taehui Bae Wooseob Kim Jinhwa Choi Mikyung Kim Shinhyuk Kang Hansoo Park |
| author_sort | Haejin Joo |
| collection | DOAJ |
| description | Polydimethylsiloxane (PDMS) is a biocompatible polymer that has been applied in many fields. However, the surface hydrophobicity of PDMS can limit successful implementation, and this must be reduced by surface modification to improve biocompatibility. In this study, we modified the PDMS surface with a hydrogel and investigated the effect of this on hydrophilicity, bacterial adhesion, cell viability, immune response, and biocompatibility of PDMS. Hydrogels were created from hyaluronic acid and gelatin using a Schiff-base reaction. The PDMS surface and hydrogel were characterized using nuclear magnetic resonance, X-ray photoelectron spectroscopy, attenuated total reflection Fourier-transform infrared spectroscopy, and scanning electron microscopy. The hydrophilicity of the surface was confirmed via a decrease in the water contact angle. Bacterial anti-adhesion was demonstrated for <i>Pseudomonas aeruginosa, Ralstonia pickettii,</i> and <i>Staphylococcus epidermidis</i>, and viability and improved distribution of human-derived adipose stem cells were also confirmed. Decreased capsular tissue responses were observed in vivo with looser collagen distribution and reduced cytokine expression on the hydrogel-coated surface. Hydrogel coating on treated PDMS is a promising method to improve the surface hydrophilicity and biocompatibility for surface modification of biomedical applications. |
| first_indexed | 2024-03-09T00:48:40Z |
| format | Article |
| id | doaj.art-7d5de291198b4bbb99bf38bdf62cd0dc |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T00:48:40Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7d5de291198b4bbb99bf38bdf62cd0dc2023-12-11T17:20:08ZengMDPI AGPharmaceutics1999-49232021-02-0113226910.3390/pharmaceutics13020269Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced FibrosisHaejin Joo0Jonghyun Park1Chanutchamon Sutthiwanjampa2Hankoo Kim3Taehui Bae4Wooseob Kim5Jinhwa Choi6Mikyung Kim7Shinhyuk Kang8Hansoo Park9Department of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaDepartment of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Seoul 06973, KoreaDepartment of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaDepartment of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Seoul 06973, KoreaDepartment of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Seoul 06973, KoreaDepartment of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Seoul 06973, KoreaDepartment of Radiation Oncology, Chung-Ang University Hospital, Seoul 06973, KoreaDepartment of Pathology, Chung-Ang University Hospital, Seoul 06973, KoreaDepartment of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Seoul 06973, KoreaDepartment of Integrative Engineering, Chung-Ang University, Seoul 06974, KoreaPolydimethylsiloxane (PDMS) is a biocompatible polymer that has been applied in many fields. However, the surface hydrophobicity of PDMS can limit successful implementation, and this must be reduced by surface modification to improve biocompatibility. In this study, we modified the PDMS surface with a hydrogel and investigated the effect of this on hydrophilicity, bacterial adhesion, cell viability, immune response, and biocompatibility of PDMS. Hydrogels were created from hyaluronic acid and gelatin using a Schiff-base reaction. The PDMS surface and hydrogel were characterized using nuclear magnetic resonance, X-ray photoelectron spectroscopy, attenuated total reflection Fourier-transform infrared spectroscopy, and scanning electron microscopy. The hydrophilicity of the surface was confirmed via a decrease in the water contact angle. Bacterial anti-adhesion was demonstrated for <i>Pseudomonas aeruginosa, Ralstonia pickettii,</i> and <i>Staphylococcus epidermidis</i>, and viability and improved distribution of human-derived adipose stem cells were also confirmed. Decreased capsular tissue responses were observed in vivo with looser collagen distribution and reduced cytokine expression on the hydrogel-coated surface. Hydrogel coating on treated PDMS is a promising method to improve the surface hydrophilicity and biocompatibility for surface modification of biomedical applications.https://www.mdpi.com/1999-4923/13/2/269polydimethylsiloxanesurface coatinghydrogelSchiff-base reactionhydrophilicitybiocompatibility |
| spellingShingle | Haejin Joo Jonghyun Park Chanutchamon Sutthiwanjampa Hankoo Kim Taehui Bae Wooseob Kim Jinhwa Choi Mikyung Kim Shinhyuk Kang Hansoo Park Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis Pharmaceutics polydimethylsiloxane surface coating hydrogel Schiff-base reaction hydrophilicity biocompatibility |
| title | Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis |
| title_full | Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis |
| title_fullStr | Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis |
| title_full_unstemmed | Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis |
| title_short | Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis |
| title_sort | surface coating with hyaluronic acid gelatin crosslinked hydrogel on gelatin conjugated poly dimethylsiloxane for implantable medical device induced fibrosis |
| topic | polydimethylsiloxane surface coating hydrogel Schiff-base reaction hydrophilicity biocompatibility |
| url | https://www.mdpi.com/1999-4923/13/2/269 |
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