Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results
Purpose : To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using 125 I radioactive seeds for multiple pulmonary metastatic tumors. Material and methods : Between September 2013 and December 2015, 22 patients with multi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-04-01
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| Series: | Journal of Contemporary Brachytherapy |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Computed-tomography-guided-implantation-of-125-I-seeds-brachytherapy-for-recurrent-multiple-pulmonary-oligometastases-initial-experience-and-results,54,29776,1,1.html |
| _version_ | 1818972013982646272 |
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| author | Jie Li Lijuan Zhang Wenhuan Xu Teng Wang Leyuan Zhou Qigen Xie Weiguo Wang Yanyan Hua |
| author_facet | Jie Li Lijuan Zhang Wenhuan Xu Teng Wang Leyuan Zhou Qigen Xie Weiguo Wang Yanyan Hua |
| author_sort | Jie Li |
| collection | DOAJ |
| description | Purpose : To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using 125 I radioactive seeds for multiple pulmonary metastatic tumors.
Material and methods : Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE) therapy were considered unable to withstand stereotactic body radiation therapy (SBRT), received CT-guided 125 I brachytherapy. Clinical data were studied retrospectively. A planning target volume of 90% (D90) was 120-160 Gy for 125 I seeds with an activity of 25.9 MBq. A CT-based evaluation performed 1, 2, and 6 months’ post-implantation enabled review of local control of tumors.
Results : Twenty-two patients with 65 pulmonary metastases successfully completed treatment. The mean value for D90 for implantation for 125 I seeds was 132 Gy. Complete response (CR) + partial response (PR) was documented in 81.54%, 78.46%, and 78.46% of patients at 1, 2, and 6 months after implantation, respectively. Fourteen out of 22 patients had CR, 3 had PR, 2 had stable disease (SD), and 3 had progressive disease (PD). Most of the metastases (CR + PR + SD; 87.69% after 6 months) were controlled by implantation.
Conclusions : CT-guided 125 I brachytherapy is a safe and effective treatment for multiple pulmonary metastatic tumors, and can achieve good short-term local control, so long as the radiation dose is sufficient. |
| first_indexed | 2024-12-20T15:01:31Z |
| format | Article |
| id | doaj.art-7d6061ab0f2049bc86bef4343ea628d9 |
| institution | Directory Open Access Journal |
| issn | 1689-832X 2081-2841 |
| language | English |
| last_indexed | 2024-12-20T15:01:31Z |
| publishDate | 2017-04-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Journal of Contemporary Brachytherapy |
| spelling | doaj.art-7d6061ab0f2049bc86bef4343ea628d92022-12-21T19:36:39ZengTermedia Publishing HouseJournal of Contemporary Brachytherapy1689-832X2081-28412017-04-019213213810.5114/jcb.2017.6702329776Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and resultsJie LiLijuan ZhangWenhuan XuTeng WangLeyuan ZhouQigen XieWeiguo WangYanyan HuaPurpose : To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using 125 I radioactive seeds for multiple pulmonary metastatic tumors. Material and methods : Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE) therapy were considered unable to withstand stereotactic body radiation therapy (SBRT), received CT-guided 125 I brachytherapy. Clinical data were studied retrospectively. A planning target volume of 90% (D90) was 120-160 Gy for 125 I seeds with an activity of 25.9 MBq. A CT-based evaluation performed 1, 2, and 6 months’ post-implantation enabled review of local control of tumors. Results : Twenty-two patients with 65 pulmonary metastases successfully completed treatment. The mean value for D90 for implantation for 125 I seeds was 132 Gy. Complete response (CR) + partial response (PR) was documented in 81.54%, 78.46%, and 78.46% of patients at 1, 2, and 6 months after implantation, respectively. Fourteen out of 22 patients had CR, 3 had PR, 2 had stable disease (SD), and 3 had progressive disease (PD). Most of the metastases (CR + PR + SD; 87.69% after 6 months) were controlled by implantation. Conclusions : CT-guided 125 I brachytherapy is a safe and effective treatment for multiple pulmonary metastatic tumors, and can achieve good short-term local control, so long as the radiation dose is sufficient.https://www.termedia.pl/Computed-tomography-guided-implantation-of-125-I-seeds-brachytherapy-for-recurrent-multiple-pulmonary-oligometastases-initial-experience-and-results,54,29776,1,1.htmlbrachytherapy computed tomography <sup>125</sup>I pulmonary metastatic tumors |
| spellingShingle | Jie Li Lijuan Zhang Wenhuan Xu Teng Wang Leyuan Zhou Qigen Xie Weiguo Wang Yanyan Hua Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results Journal of Contemporary Brachytherapy brachytherapy computed tomography <sup>125</sup>I pulmonary metastatic tumors |
| title | Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results |
| title_full | Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results |
| title_fullStr | Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results |
| title_full_unstemmed | Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results |
| title_short | Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results |
| title_sort | computed tomography guided implantation of 125 i seeds brachytherapy for recurrent multiple pulmonary oligometastases initial experience and results |
| topic | brachytherapy computed tomography <sup>125</sup>I pulmonary metastatic tumors |
| url | https://www.termedia.pl/Computed-tomography-guided-implantation-of-125-I-seeds-brachytherapy-for-recurrent-multiple-pulmonary-oligometastases-initial-experience-and-results,54,29776,1,1.html |
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