Wnt and β-Catenin Signaling in the Bone Metastasis of Prostate Cancer
Wnt family proteins and β-catenin are critical for the regulation of many developmental and oncogenic processes. Wnts are secreted protein ligands which signal using a canonical pathway, and involve the transcriptional co-activator β-catenin or non-canonical pathways that are independent of β-cateni...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/10/1099 |
| _version_ | 1797514108694691840 |
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| author | Zachary Kaplan Steven P. Zielske Kristina G. Ibrahim Frank C. Cackowski |
| author_facet | Zachary Kaplan Steven P. Zielske Kristina G. Ibrahim Frank C. Cackowski |
| author_sort | Zachary Kaplan |
| collection | DOAJ |
| description | Wnt family proteins and β-catenin are critical for the regulation of many developmental and oncogenic processes. Wnts are secreted protein ligands which signal using a canonical pathway, and involve the transcriptional co-activator β-catenin or non-canonical pathways that are independent of β-catenin. Bone metastasis is unfortunately a common occurrence in prostate cancer and can be conceptualized as a series of related steps or processes, most of which are regulated by Wnt ligands and/or β-catenin. At the primary tumor site, cancer cells often take on mesenchymal properties, termed epithelial mesenchymal transition (EMT), which are regulated in part by the Wnt receptor FZD4. Then, Wnt signaling, especially Wnt5A, is of importance as the cells circulate in the blood stream. Upon arriving in the bones, cancer cells migrate and take on stem-like or tumorigenic properties, as aided through Wnt or β-catenin signaling involving CHD11, CD24, and Wnt5A. Additionally, cancer cells can become dormant and evade therapy, in part due to regulation by Wnt5A. In the bones, E-selectin can aid in the reversal of EMT, a process termed mesenchymal epithelial transition (MET), as a part of metastatic tumorigenesis. Once bone tumors are established, Wnt/β-catenin signaling is involved in the suppression of osteoblast function largely through DKK1. |
| first_indexed | 2024-03-10T06:26:58Z |
| format | Article |
| id | doaj.art-7d60676ba84c4ff99088afaad24ef7d9 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T06:26:58Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-7d60676ba84c4ff99088afaad24ef7d92023-11-22T18:53:34ZengMDPI AGLife2075-17292021-10-011110109910.3390/life11101099Wnt and β-Catenin Signaling in the Bone Metastasis of Prostate CancerZachary Kaplan0Steven P. Zielske1Kristina G. Ibrahim2Frank C. Cackowski3College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USADepartment of Oncology and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USADepartment of Oncology and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USADepartment of Oncology and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USAWnt family proteins and β-catenin are critical for the regulation of many developmental and oncogenic processes. Wnts are secreted protein ligands which signal using a canonical pathway, and involve the transcriptional co-activator β-catenin or non-canonical pathways that are independent of β-catenin. Bone metastasis is unfortunately a common occurrence in prostate cancer and can be conceptualized as a series of related steps or processes, most of which are regulated by Wnt ligands and/or β-catenin. At the primary tumor site, cancer cells often take on mesenchymal properties, termed epithelial mesenchymal transition (EMT), which are regulated in part by the Wnt receptor FZD4. Then, Wnt signaling, especially Wnt5A, is of importance as the cells circulate in the blood stream. Upon arriving in the bones, cancer cells migrate and take on stem-like or tumorigenic properties, as aided through Wnt or β-catenin signaling involving CHD11, CD24, and Wnt5A. Additionally, cancer cells can become dormant and evade therapy, in part due to regulation by Wnt5A. In the bones, E-selectin can aid in the reversal of EMT, a process termed mesenchymal epithelial transition (MET), as a part of metastatic tumorigenesis. Once bone tumors are established, Wnt/β-catenin signaling is involved in the suppression of osteoblast function largely through DKK1.https://www.mdpi.com/2075-1729/11/10/1099Wntβ-cateninbone metastasisprostate cancerWnt5Abreast cancer |
| spellingShingle | Zachary Kaplan Steven P. Zielske Kristina G. Ibrahim Frank C. Cackowski Wnt and β-Catenin Signaling in the Bone Metastasis of Prostate Cancer Life Wnt β-catenin bone metastasis prostate cancer Wnt5A breast cancer |
| title | Wnt and β-Catenin Signaling in the Bone Metastasis of Prostate Cancer |
| title_full | Wnt and β-Catenin Signaling in the Bone Metastasis of Prostate Cancer |
| title_fullStr | Wnt and β-Catenin Signaling in the Bone Metastasis of Prostate Cancer |
| title_full_unstemmed | Wnt and β-Catenin Signaling in the Bone Metastasis of Prostate Cancer |
| title_short | Wnt and β-Catenin Signaling in the Bone Metastasis of Prostate Cancer |
| title_sort | wnt and β catenin signaling in the bone metastasis of prostate cancer |
| topic | Wnt β-catenin bone metastasis prostate cancer Wnt5A breast cancer |
| url | https://www.mdpi.com/2075-1729/11/10/1099 |
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