RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activity

RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activity

Objective: Type 1 diabetes (T1D) is characterized by autoimmune-associated β-cell loss, insulin insufficiency, and hyperglycemia. Although TNFα signaling is associated with β-cell loss and hyperglycemia in non-obese diabetic mice and human T1D, the molecular mechanisms of β-cell TNF receptor signali...

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Bibliographic Details
Main Authors: Christopher J. Contreras, Noyonika Mukherjee, Renato C.S. Branco, Li Lin, Meghan F. Hogan, Erica P. Cai, Andrew A. Oberst, Steven E. Kahn, Andrew T. Templin
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Molecular Metabolism
Subjects:
RIPK1
RIPK3
β-cell death
Type 1 diabetes
TNFα
Caspase
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782200151X

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