Divergent evolution among teleost V1r receptor genes.
The survival of vertebrate species is dependent on the ability of individuals to adequately interact with each other, a function often mediated by the olfactory system. Diverse olfactory receptor repertoires are used by this system to recognize chemicals. Among these receptors, the V1rs, encoded by...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2007-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC1849887?pdf=render |
| _version_ | 1819236112441278464 |
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| author | Patrick Pfister Jerome Randall Juan I Montoya-Burgos Ivan Rodriguez |
| author_facet | Patrick Pfister Jerome Randall Juan I Montoya-Burgos Ivan Rodriguez |
| author_sort | Patrick Pfister |
| collection | DOAJ |
| description | The survival of vertebrate species is dependent on the ability of individuals to adequately interact with each other, a function often mediated by the olfactory system. Diverse olfactory receptor repertoires are used by this system to recognize chemicals. Among these receptors, the V1rs, encoded by a very large gene family in most mammals, are able to detect pheromones. Teleosts, which also express V1r receptors, possess a very limited V1r repertoire. Here, taking advantage of the possibility to unequivocally identify V1r orthologs in teleosts, we analyzed the olfactory expression and evolutionary constraints of a pair of clustered fish V1r receptor genes, V1r1 and V1r2. Orthologs of the two genes were found in zebrafish, medaka, and threespine stickleback, but a single representative was observed in tetraodontidae species. Analysis of V1r1 and V1r2 sequences from 12 different euteleost species indicate different evolutionary rates between the two paralogous genes, leading to a highly conserved V1r2 gene and a V1r1 gene under more relaxed selective constraint. Moreover, positively-selected sites were detected in specific branches of the V1r1 clade. Our results suggest a conserved agonist specificity of the V1R2 receptor between euteleost species, its loss in the tetraodontidae lineage, and the acquisition of different chemosensory characteristics for the V1R1 receptor. |
| first_indexed | 2024-12-23T12:59:15Z |
| format | Article |
| id | doaj.art-7d611c17b912444aaeb5bd66dcc39784 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T12:59:15Z |
| publishDate | 2007-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7d611c17b912444aaeb5bd66dcc397842022-12-21T17:46:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032007-01-0124e37910.1371/journal.pone.0000379Divergent evolution among teleost V1r receptor genes.Patrick PfisterJerome RandallJuan I Montoya-BurgosIvan RodriguezThe survival of vertebrate species is dependent on the ability of individuals to adequately interact with each other, a function often mediated by the olfactory system. Diverse olfactory receptor repertoires are used by this system to recognize chemicals. Among these receptors, the V1rs, encoded by a very large gene family in most mammals, are able to detect pheromones. Teleosts, which also express V1r receptors, possess a very limited V1r repertoire. Here, taking advantage of the possibility to unequivocally identify V1r orthologs in teleosts, we analyzed the olfactory expression and evolutionary constraints of a pair of clustered fish V1r receptor genes, V1r1 and V1r2. Orthologs of the two genes were found in zebrafish, medaka, and threespine stickleback, but a single representative was observed in tetraodontidae species. Analysis of V1r1 and V1r2 sequences from 12 different euteleost species indicate different evolutionary rates between the two paralogous genes, leading to a highly conserved V1r2 gene and a V1r1 gene under more relaxed selective constraint. Moreover, positively-selected sites were detected in specific branches of the V1r1 clade. Our results suggest a conserved agonist specificity of the V1R2 receptor between euteleost species, its loss in the tetraodontidae lineage, and the acquisition of different chemosensory characteristics for the V1R1 receptor.http://europepmc.org/articles/PMC1849887?pdf=render |
| spellingShingle | Patrick Pfister Jerome Randall Juan I Montoya-Burgos Ivan Rodriguez Divergent evolution among teleost V1r receptor genes. PLoS ONE |
| title | Divergent evolution among teleost V1r receptor genes. |
| title_full | Divergent evolution among teleost V1r receptor genes. |
| title_fullStr | Divergent evolution among teleost V1r receptor genes. |
| title_full_unstemmed | Divergent evolution among teleost V1r receptor genes. |
| title_short | Divergent evolution among teleost V1r receptor genes. |
| title_sort | divergent evolution among teleost v1r receptor genes |
| url | http://europepmc.org/articles/PMC1849887?pdf=render |
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