Blood biomarkers for dementia in Hispanic and non‐Hispanic White adults
Abstract Introduction The study evaluated if blood markers reflecting diverse biological pathways differentiate clinical diagnostic groups among Hispanic and non‐Hispanic White adults. Methods Within Hispanic (n = 1193) and non‐Hispanic White (n = 650) participants, serum total tau (t‐tau), neurofil...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12164 |
| _version_ | 1798022853478580224 |
|---|---|
| author | Mitzi M. Gonzales Meghan I. Short Claudia L. Satizabal Sid O’ Bryant Russel P. Tracy Habil Zare Sudha Seshadri |
| author_facet | Mitzi M. Gonzales Meghan I. Short Claudia L. Satizabal Sid O’ Bryant Russel P. Tracy Habil Zare Sudha Seshadri |
| author_sort | Mitzi M. Gonzales |
| collection | DOAJ |
| description | Abstract Introduction The study evaluated if blood markers reflecting diverse biological pathways differentiate clinical diagnostic groups among Hispanic and non‐Hispanic White adults. Methods Within Hispanic (n = 1193) and non‐Hispanic White (n = 650) participants, serum total tau (t‐tau), neurofilament light (NfL), ubiquitin carboxyl‐terminal hydrolase LI, glial fibrillary acidic protein (GFAP), soluble cluster of differentiation‐14, and chitinase‐3‐like protein 1 (YKL‐40) were quantified. Mixed‐effects partial proportional odds ordinal logistic regression and linear mixed‐effects models were used to evaluate the association of biomarkers with diagnostic group and cognition, adjusting for age, sex, ethnicity, apolipoprotein E ε4, education, and site. Results T‐tau, NfL, GFAP, and YKL‐40 discriminated between diagnostic groups (receiver operating curve: 0.647–0.873). Higher t‐tau (odds ratio [OR] = 1.671, 95% confidence interval [CI] = 1.457–1.917, P < .001), NfL (OR = 2.150, 95% CI = 1.819–2.542, P < .001), GFAP (OR = 2.283, 95% CI = 1.915–2.722, P < .001), and YKL‐40 (OR = 1.288, 95% CI = 1.125–1.475, P < .001) were associated with increased likelihood of dementia relative to cognitively unimpaired and mild cognitive impairment groups. Higher NfL was associated with poorer global cognition (β = –0.455, standard error [SE] = 0.083, P < .001), semantic fluency (β = –0.410, SE = 0.133, P = .002), attention/processing speed (β = 2.880, SE = 0.801, P < .001), and executive function (β = 5.965, SE = 2.037, P = .003). Higher GFAP was associated with poorer global cognition (β = –0.345, SE = 0.092, P = .001), learning (β = –1.426, SE = 0.359, P < .001), and memory (β = –0.890, SE = 0.266, P < .001). Higher YKL‐40 (β = –0.537, SE = 0.186, P = .004) was associated with lower memory scores. Interactions with ethnicity were observed for learning (NfL, GFAP, YKL‐40), memory (NfL, GFAP), and semantic fluency (NfL; interaction terms P < .008), which were generally no longer significant in a demographically matched subset of Hispanic and non‐Hispanic White participants. Discussion Blood biomarkers of neuronal/axonal and glial injury differentiated between clinical diagnostic groups in a bi‐ethnic cohort of Hispanic and non‐Hispanic Whites. Our results add to the growing literature indicating that blood biomarkers may be viable tools for detecting neurodegenerative conditions and highlight the importance of validation in diverse cohorts. |
| first_indexed | 2024-04-11T17:36:42Z |
| format | Article |
| id | doaj.art-7d62147a3b6a411a928c3811398ae4cc |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-11T17:36:42Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-7d62147a3b6a411a928c3811398ae4cc2022-12-22T04:11:35ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372021-01-0171n/an/a10.1002/trc2.12164Blood biomarkers for dementia in Hispanic and non‐Hispanic White adultsMitzi M. Gonzales0Meghan I. Short1Claudia L. Satizabal2Sid O’ Bryant3Russel P. Tracy4Habil Zare5Sudha Seshadri6Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases University of Texas Health Science Center San Antonio Texas USAGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases University of Texas Health Science Center San Antonio Texas USAGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases University of Texas Health Science Center San Antonio Texas USAInstitute for Translational Research and Department of Pharmacology & Neuroscience University of North Texas Health Science Center Fort Worth Texas USADepartments of Pathology and Laboratory Medicine, and Biochemistry Larner College of Medicine, University of Vermont Burlington Vermont USAGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases University of Texas Health Science Center San Antonio Texas USAGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases University of Texas Health Science Center San Antonio Texas USAAbstract Introduction The study evaluated if blood markers reflecting diverse biological pathways differentiate clinical diagnostic groups among Hispanic and non‐Hispanic White adults. Methods Within Hispanic (n = 1193) and non‐Hispanic White (n = 650) participants, serum total tau (t‐tau), neurofilament light (NfL), ubiquitin carboxyl‐terminal hydrolase LI, glial fibrillary acidic protein (GFAP), soluble cluster of differentiation‐14, and chitinase‐3‐like protein 1 (YKL‐40) were quantified. Mixed‐effects partial proportional odds ordinal logistic regression and linear mixed‐effects models were used to evaluate the association of biomarkers with diagnostic group and cognition, adjusting for age, sex, ethnicity, apolipoprotein E ε4, education, and site. Results T‐tau, NfL, GFAP, and YKL‐40 discriminated between diagnostic groups (receiver operating curve: 0.647–0.873). Higher t‐tau (odds ratio [OR] = 1.671, 95% confidence interval [CI] = 1.457–1.917, P < .001), NfL (OR = 2.150, 95% CI = 1.819–2.542, P < .001), GFAP (OR = 2.283, 95% CI = 1.915–2.722, P < .001), and YKL‐40 (OR = 1.288, 95% CI = 1.125–1.475, P < .001) were associated with increased likelihood of dementia relative to cognitively unimpaired and mild cognitive impairment groups. Higher NfL was associated with poorer global cognition (β = –0.455, standard error [SE] = 0.083, P < .001), semantic fluency (β = –0.410, SE = 0.133, P = .002), attention/processing speed (β = 2.880, SE = 0.801, P < .001), and executive function (β = 5.965, SE = 2.037, P = .003). Higher GFAP was associated with poorer global cognition (β = –0.345, SE = 0.092, P = .001), learning (β = –1.426, SE = 0.359, P < .001), and memory (β = –0.890, SE = 0.266, P < .001). Higher YKL‐40 (β = –0.537, SE = 0.186, P = .004) was associated with lower memory scores. Interactions with ethnicity were observed for learning (NfL, GFAP, YKL‐40), memory (NfL, GFAP), and semantic fluency (NfL; interaction terms P < .008), which were generally no longer significant in a demographically matched subset of Hispanic and non‐Hispanic White participants. Discussion Blood biomarkers of neuronal/axonal and glial injury differentiated between clinical diagnostic groups in a bi‐ethnic cohort of Hispanic and non‐Hispanic Whites. Our results add to the growing literature indicating that blood biomarkers may be viable tools for detecting neurodegenerative conditions and highlight the importance of validation in diverse cohorts.https://doi.org/10.1002/trc2.12164Alzheimer's diseaseblood biomarkerschitinase‐3‐like protein 1ethnicityglial fibrillary acidic proteinHispanic |
| spellingShingle | Mitzi M. Gonzales Meghan I. Short Claudia L. Satizabal Sid O’ Bryant Russel P. Tracy Habil Zare Sudha Seshadri Blood biomarkers for dementia in Hispanic and non‐Hispanic White adults Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease blood biomarkers chitinase‐3‐like protein 1 ethnicity glial fibrillary acidic protein Hispanic |
| title | Blood biomarkers for dementia in Hispanic and non‐Hispanic White adults |
| title_full | Blood biomarkers for dementia in Hispanic and non‐Hispanic White adults |
| title_fullStr | Blood biomarkers for dementia in Hispanic and non‐Hispanic White adults |
| title_full_unstemmed | Blood biomarkers for dementia in Hispanic and non‐Hispanic White adults |
| title_short | Blood biomarkers for dementia in Hispanic and non‐Hispanic White adults |
| title_sort | blood biomarkers for dementia in hispanic and non hispanic white adults |
| topic | Alzheimer's disease blood biomarkers chitinase‐3‐like protein 1 ethnicity glial fibrillary acidic protein Hispanic |
| url | https://doi.org/10.1002/trc2.12164 |
| work_keys_str_mv | AT mitzimgonzales bloodbiomarkersfordementiainhispanicandnonhispanicwhiteadults AT meghanishort bloodbiomarkersfordementiainhispanicandnonhispanicwhiteadults AT claudialsatizabal bloodbiomarkersfordementiainhispanicandnonhispanicwhiteadults AT sidobryant bloodbiomarkersfordementiainhispanicandnonhispanicwhiteadults AT russelptracy bloodbiomarkersfordementiainhispanicandnonhispanicwhiteadults AT habilzare bloodbiomarkersfordementiainhispanicandnonhispanicwhiteadults AT sudhaseshadri bloodbiomarkersfordementiainhispanicandnonhispanicwhiteadults |