Leukocyte-Dependent Regulation of Cardiac Fibrosis
Cardiac fibrosis begins as an intrinsic response to injury or ageing that functions to preserve the tissue from further damage. Fibrosis results from activated cardiac myofibroblasts, which secrete extracellular matrix (ECM) proteins in an effort to replace damaged tissue; however, excessive ECM dep...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00301/full |
| _version_ | 1828543200306921472 |
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| author | Ama Dedo Okyere Douglas G. Tilley |
| author_facet | Ama Dedo Okyere Douglas G. Tilley |
| author_sort | Ama Dedo Okyere |
| collection | DOAJ |
| description | Cardiac fibrosis begins as an intrinsic response to injury or ageing that functions to preserve the tissue from further damage. Fibrosis results from activated cardiac myofibroblasts, which secrete extracellular matrix (ECM) proteins in an effort to replace damaged tissue; however, excessive ECM deposition leads to pathological fibrotic remodeling. At this extent, fibrosis gravely disturbs myocardial compliance, and ultimately leads to adverse outcomes like heart failure with heightened mortality. As such, understanding the complexity behind fibrotic remodeling has been a focal point of cardiac research in recent years. Resident cardiac fibroblasts and activated myofibroblasts have been proven integral to the fibrotic response; however, several findings point to additional cell types that may contribute to the development of pathological fibrosis. For one, leukocytes expand in number after injury and exhibit high plasticity, thus their distinct role(s) in cardiac fibrosis is an ongoing and controversial field of study. This review summarizes current findings, focusing on both direct and indirect leukocyte-mediated mechanisms of fibrosis, which may provide novel targeted strategies against fibrotic remodeling. |
| first_indexed | 2024-12-12T02:09:42Z |
| format | Article |
| id | doaj.art-7d62e618f7674d1289c739c345bfe539 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T02:09:42Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-7d62e618f7674d1289c739c345bfe5392022-12-22T00:41:57ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-04-011110.3389/fphys.2020.00301514777Leukocyte-Dependent Regulation of Cardiac FibrosisAma Dedo OkyereDouglas G. TilleyCardiac fibrosis begins as an intrinsic response to injury or ageing that functions to preserve the tissue from further damage. Fibrosis results from activated cardiac myofibroblasts, which secrete extracellular matrix (ECM) proteins in an effort to replace damaged tissue; however, excessive ECM deposition leads to pathological fibrotic remodeling. At this extent, fibrosis gravely disturbs myocardial compliance, and ultimately leads to adverse outcomes like heart failure with heightened mortality. As such, understanding the complexity behind fibrotic remodeling has been a focal point of cardiac research in recent years. Resident cardiac fibroblasts and activated myofibroblasts have been proven integral to the fibrotic response; however, several findings point to additional cell types that may contribute to the development of pathological fibrosis. For one, leukocytes expand in number after injury and exhibit high plasticity, thus their distinct role(s) in cardiac fibrosis is an ongoing and controversial field of study. This review summarizes current findings, focusing on both direct and indirect leukocyte-mediated mechanisms of fibrosis, which may provide novel targeted strategies against fibrotic remodeling.https://www.frontiersin.org/article/10.3389/fphys.2020.00301/fullcardiac fibrosisneutrophilmonocyte macrophagemast cellslymphocytesdendritic cells |
| spellingShingle | Ama Dedo Okyere Douglas G. Tilley Leukocyte-Dependent Regulation of Cardiac Fibrosis Frontiers in Physiology cardiac fibrosis neutrophil monocyte macrophage mast cells lymphocytes dendritic cells |
| title | Leukocyte-Dependent Regulation of Cardiac Fibrosis |
| title_full | Leukocyte-Dependent Regulation of Cardiac Fibrosis |
| title_fullStr | Leukocyte-Dependent Regulation of Cardiac Fibrosis |
| title_full_unstemmed | Leukocyte-Dependent Regulation of Cardiac Fibrosis |
| title_short | Leukocyte-Dependent Regulation of Cardiac Fibrosis |
| title_sort | leukocyte dependent regulation of cardiac fibrosis |
| topic | cardiac fibrosis neutrophil monocyte macrophage mast cells lymphocytes dendritic cells |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00301/full |
| work_keys_str_mv | AT amadedookyere leukocytedependentregulationofcardiacfibrosis AT douglasgtilley leukocytedependentregulationofcardiacfibrosis |