Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT

Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT

Boron clusters attract considerable attention as promising therapeutic tools for boron neutron capture therapy (BNCT). They combine high boron content with high chemical and biological stability, biorthogonality, and low toxicity. The development of oligonucleotide-based constructs and nucleic acid-...

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Bibliographic Details
Main Authors: Darya Sergeevna Novopashina, Mariya Alexandrovna Vorobyeva, Alya Venyaminova
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Chemistry
Subjects:
boron cluster
oligonucleotide conjugate
conjugation method
pre- and post-synthetic modification
BNCT
boron neutron capture therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.619052/full

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