Case Report: Large nested variant urothelial carcinoma –invasive malignancy masquerading as low grade disease [v1; ref status: indexed, http://f1000r.es/4xb]
Introduction The large nested variant of urothelial carcinoma (LNVUC) is a newly described and rare subtype of urothelial carcinoma. It is characterised by bland cytological features and a large nested architecture similar in appearance to low grade urothelial carcinoma with an inverted growth patte...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2014-12-01
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| Online Access: | http://f1000research.com/articles/3-314/v1 |
| _version_ | 1828318825428287488 |
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| author | Andrew Keller Ai Jye Lim Ahmad Ali |
| author_facet | Andrew Keller Ai Jye Lim Ahmad Ali |
| author_sort | Andrew Keller |
| collection | DOAJ |
| description | Introduction The large nested variant of urothelial carcinoma (LNVUC) is a newly described and rare subtype of urothelial carcinoma. It is characterised by bland cytological features and a large nested architecture similar in appearance to low grade urothelial carcinoma with an inverted growth pattern. To date only 23 cases in a single series have been described. Case Report We describe the case of a 59 year old male with LNVUC whose tumour was initially misdiagnosed as a non-invasive low grade urothelial carcinoma. At a subsequent re-resection, his tumour was correctly re-classified as LNVUC with extensive invasion of the muscularis propria. Radical cystectomy and formation of an ileal conduit was performed. His operative specimen revealed invasion of prostatic stroma and perivesical fat, with all surgical margins clear. He is currently free from clinical recurrence 12 months after his cystectomy. Conclusion LNVUC is a newly described and rare urothelial carcinoma subtype. It characteristically possesses bland cytological features and may mimic low grade urothelial cancer. Despite its bland appearance it behaves aggressively with invasion, metastasis and death being common. |
| first_indexed | 2024-04-13T17:48:56Z |
| format | Article |
| id | doaj.art-7d6362b365fc4487bf16454b2165badf |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-13T17:48:56Z |
| publishDate | 2014-12-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-7d6362b365fc4487bf16454b2165badf2022-12-22T02:36:49ZengF1000 Research LtdF1000Research2046-14022014-12-01310.12688/f1000research.5966.16383Case Report: Large nested variant urothelial carcinoma –invasive malignancy masquerading as low grade disease [v1; ref status: indexed, http://f1000r.es/4xb]Andrew Keller0Ai Jye Lim1Ahmad Ali2Department of Urology, Ipswich General Hospital, Ipswich, QLD, 4305, AustraliaDepartment of Anatomical Pathology, Princess Alexandra Hospital, Woolloongabba, QLD, 4102, AustraliaDepartment of Urology, Ipswich General Hospital, Ipswich, QLD, 4305, AustraliaIntroduction The large nested variant of urothelial carcinoma (LNVUC) is a newly described and rare subtype of urothelial carcinoma. It is characterised by bland cytological features and a large nested architecture similar in appearance to low grade urothelial carcinoma with an inverted growth pattern. To date only 23 cases in a single series have been described. Case Report We describe the case of a 59 year old male with LNVUC whose tumour was initially misdiagnosed as a non-invasive low grade urothelial carcinoma. At a subsequent re-resection, his tumour was correctly re-classified as LNVUC with extensive invasion of the muscularis propria. Radical cystectomy and formation of an ileal conduit was performed. His operative specimen revealed invasion of prostatic stroma and perivesical fat, with all surgical margins clear. He is currently free from clinical recurrence 12 months after his cystectomy. Conclusion LNVUC is a newly described and rare urothelial carcinoma subtype. It characteristically possesses bland cytological features and may mimic low grade urothelial cancer. Despite its bland appearance it behaves aggressively with invasion, metastasis and death being common.http://f1000research.com/articles/3-314/v1Genitourinary Cancers |
| spellingShingle | Andrew Keller Ai Jye Lim Ahmad Ali Case Report: Large nested variant urothelial carcinoma –invasive malignancy masquerading as low grade disease [v1; ref status: indexed, http://f1000r.es/4xb] F1000Research Genitourinary Cancers |
| title | Case Report: Large nested variant urothelial carcinoma –invasive malignancy masquerading as low grade disease [v1; ref status: indexed, http://f1000r.es/4xb] |
| title_full | Case Report: Large nested variant urothelial carcinoma –invasive malignancy masquerading as low grade disease [v1; ref status: indexed, http://f1000r.es/4xb] |
| title_fullStr | Case Report: Large nested variant urothelial carcinoma –invasive malignancy masquerading as low grade disease [v1; ref status: indexed, http://f1000r.es/4xb] |
| title_full_unstemmed | Case Report: Large nested variant urothelial carcinoma –invasive malignancy masquerading as low grade disease [v1; ref status: indexed, http://f1000r.es/4xb] |
| title_short | Case Report: Large nested variant urothelial carcinoma –invasive malignancy masquerading as low grade disease [v1; ref status: indexed, http://f1000r.es/4xb] |
| title_sort | case report large nested variant urothelial carcinoma invasive malignancy masquerading as low grade disease v1 ref status indexed http f1000r es 4xb |
| topic | Genitourinary Cancers |
| url | http://f1000research.com/articles/3-314/v1 |
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