Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Introduction and aim: Endogenous sex hormones are associated with the risk of diabetes and metabolic syndrome. Recent studies suggested the role of these hormones in nonalcoholic fatty liver disease (NAFLD). We conducted a systematic review and meta-analysis of observational studies investigating th...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-05-01
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| Series: | Annals of Hepatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119304119 |
| _version_ | 1830513774998585344 |
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| author | Veeravich Jaruvongvanich Anawin Sanguankeo Tanawan Riangwiwat Sikarin Upala |
| author_facet | Veeravich Jaruvongvanich Anawin Sanguankeo Tanawan Riangwiwat Sikarin Upala |
| author_sort | Veeravich Jaruvongvanich |
| collection | DOAJ |
| description | Introduction and aim: Endogenous sex hormones are associated with the risk of diabetes and metabolic syndrome. Recent studies suggested the role of these hormones in nonalcoholic fatty liver disease (NAFLD). We conducted a systematic review and meta-analysis of observational studies investigating the association between sex hormones and NAFLD. Material and Methods: A comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through April 2016. The inclusion criterion was the observational studies that assessed the association of serum total testosterone (TT) and sex-hormone binding globulin (SHBG) and NAFLD. We calculated pooled effect estimates of TT and SHBG with 95% confidence intervals (CI) comparing between subjects with and without NAFLD by using random-effects model. Results: Sixteen trials comprising 13,721 men and 5,840 women met the inclusion criteria. TT levels were lower in men with NAFLD (MD = -2.78 nmol/l, 95%CI -3.40 to -2.15, I2 = 99%) than in those without. Men with higher TT levels had lower odds of NAFLD whereas higher TT levels increased the odds of NAFLD in women. In both sexes, SHBG levels were lower in patients with NAFLD than controls and this inverse association was stronger in women than men and higher SHBG levels were associated with reduced odds of NAFLD. Conclusion: Our meta-anal-ysis demonstrated a sex-dependent association between TT and NAFLD. Lower TT levels are associated with men with NAFLD and inversely associated with women with NAFLD, whereas higher SHBG levels are associated with lower NAFLD odds in both men and women. |
| first_indexed | 2024-12-22T02:51:08Z |
| format | Article |
| id | doaj.art-7d637e9a8bc24b08888afd12ec978b3e |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-22T02:51:08Z |
| publishDate | 2017-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-7d637e9a8bc24b08888afd12ec978b3e2022-12-21T18:41:23ZengElsevierAnnals of Hepatology1665-26812017-05-01163382394Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-AnalysisVeeravich Jaruvongvanich0Anawin Sanguankeo1Tanawan Riangwiwat2Sikarin Upala3Department of Internal Medicine, University of Hawaii, Honolulu, HI, USA; Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Correspondence and reprint request:Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons,Cooperstown, NY, USA; Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, ThailandDepartment of Internal Medicine, University of Hawaii, Honolulu, HI, USADepartment of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons,Cooperstown, NY, USA; Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, ThailandIntroduction and aim: Endogenous sex hormones are associated with the risk of diabetes and metabolic syndrome. Recent studies suggested the role of these hormones in nonalcoholic fatty liver disease (NAFLD). We conducted a systematic review and meta-analysis of observational studies investigating the association between sex hormones and NAFLD. Material and Methods: A comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through April 2016. The inclusion criterion was the observational studies that assessed the association of serum total testosterone (TT) and sex-hormone binding globulin (SHBG) and NAFLD. We calculated pooled effect estimates of TT and SHBG with 95% confidence intervals (CI) comparing between subjects with and without NAFLD by using random-effects model. Results: Sixteen trials comprising 13,721 men and 5,840 women met the inclusion criteria. TT levels were lower in men with NAFLD (MD = -2.78 nmol/l, 95%CI -3.40 to -2.15, I2 = 99%) than in those without. Men with higher TT levels had lower odds of NAFLD whereas higher TT levels increased the odds of NAFLD in women. In both sexes, SHBG levels were lower in patients with NAFLD than controls and this inverse association was stronger in women than men and higher SHBG levels were associated with reduced odds of NAFLD. Conclusion: Our meta-anal-ysis demonstrated a sex-dependent association between TT and NAFLD. Lower TT levels are associated with men with NAFLD and inversely associated with women with NAFLD, whereas higher SHBG levels are associated with lower NAFLD odds in both men and women.http://www.sciencedirect.com/science/article/pii/S1665268119304119Meta-analysisNon-Alcoholic Fatty Liver DiseaseSex hormoneSex-hormone binding globulinTestosterone |
| spellingShingle | Veeravich Jaruvongvanich Anawin Sanguankeo Tanawan Riangwiwat Sikarin Upala Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Annals of Hepatology Meta-analysis Non-Alcoholic Fatty Liver Disease Sex hormone Sex-hormone binding globulin Testosterone |
| title | Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis |
| title_full | Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis |
| title_fullStr | Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis |
| title_short | Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis |
| title_sort | testosterone sex hormone binding globulin and nonalcoholic fatty liver disease a systematic review and meta analysis |
| topic | Meta-analysis Non-Alcoholic Fatty Liver Disease Sex hormone Sex-hormone binding globulin Testosterone |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119304119 |
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