Photodynamic eradication of intratumoral microbiota with bacteria‐targeted micelles overcomes gemcitabine resistance of pancreatic cancer
Abstract Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression, immunosurveillance, metastasis, and chemosensitivity. Particularly, in pancreatic ductal adenocarcinoma, tumor‐resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitab...
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Aggregate |
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| Online Access: | https://doi.org/10.1002/agt2.423 |
| _version_ | 1797303041259470848 |
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| author | Renfa Liu Huanyu Yang Shuai Qu Peipei Yang Xin Zhi Yunxue Xu Zhifei Dai Linxue Qian |
| author_facet | Renfa Liu Huanyu Yang Shuai Qu Peipei Yang Xin Zhi Yunxue Xu Zhifei Dai Linxue Qian |
| author_sort | Renfa Liu |
| collection | DOAJ |
| description | Abstract Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression, immunosurveillance, metastasis, and chemosensitivity. Particularly, in pancreatic ductal adenocarcinoma, tumor‐resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine (Gem) into its inactive form, thus rendering chemotherapy ineffective. Herein, a strategy for selectively eradicating intratumoral bacteria was described for overcoming Gem resistance in a pancreatic cancer animal model. An antimicrobial peptide was linked with photosensitizer through a poly (ethylene glycol) chain, which can self‐assemble into micelles with a diameter of ∼20 nm. The micelles could efficiently kill bacteria under light irradiation by inducing membrane depolarization, thereby inhibiting Gem metabolism. In a bacteria‐resident pancreatic cancer animal model, the selective photodynamic eradication of intratumoral bacteria was demonstrated to efficiently reverse Gem resistance. This research highlights antibacterial photodynamic therapy as a promising adjuvant strategy for cancer therapy by modulating intratumoral microbiota. |
| first_indexed | 2024-03-07T23:47:15Z |
| format | Article |
| id | doaj.art-7d64088f939b4e4aa4a3e7ab2a186800 |
| institution | Directory Open Access Journal |
| issn | 2692-4560 |
| language | English |
| last_indexed | 2024-03-07T23:47:15Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aggregate |
| spelling | doaj.art-7d64088f939b4e4aa4a3e7ab2a1868002024-02-19T11:04:10ZengWileyAggregate2692-45602024-02-0151n/an/a10.1002/agt2.423Photodynamic eradication of intratumoral microbiota with bacteria‐targeted micelles overcomes gemcitabine resistance of pancreatic cancerRenfa Liu0Huanyu Yang1Shuai Qu2Peipei Yang3Xin Zhi4Yunxue Xu5Zhifei Dai6Linxue Qian7Department of Biomedical Engineering College of Future Technology National Biomedical Imaging Center Peking University Beijing ChinaDepartment of Ultrasound Beijing Friendship Hospital Capital Medical University Beijing ChinaDepartment of Biomedical Engineering College of Future Technology National Biomedical Imaging Center Peking University Beijing ChinaDepartment of Ultrasound Beijing Friendship Hospital Capital Medical University Beijing ChinaDepartment of Ultrasound Beijing Friendship Hospital Capital Medical University Beijing ChinaDepartment of Biomedical Engineering College of Future Technology National Biomedical Imaging Center Peking University Beijing ChinaDepartment of Biomedical Engineering College of Future Technology National Biomedical Imaging Center Peking University Beijing ChinaDepartment of Ultrasound Beijing Friendship Hospital Capital Medical University Beijing ChinaAbstract Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression, immunosurveillance, metastasis, and chemosensitivity. Particularly, in pancreatic ductal adenocarcinoma, tumor‐resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine (Gem) into its inactive form, thus rendering chemotherapy ineffective. Herein, a strategy for selectively eradicating intratumoral bacteria was described for overcoming Gem resistance in a pancreatic cancer animal model. An antimicrobial peptide was linked with photosensitizer through a poly (ethylene glycol) chain, which can self‐assemble into micelles with a diameter of ∼20 nm. The micelles could efficiently kill bacteria under light irradiation by inducing membrane depolarization, thereby inhibiting Gem metabolism. In a bacteria‐resident pancreatic cancer animal model, the selective photodynamic eradication of intratumoral bacteria was demonstrated to efficiently reverse Gem resistance. This research highlights antibacterial photodynamic therapy as a promising adjuvant strategy for cancer therapy by modulating intratumoral microbiota.https://doi.org/10.1002/agt2.423antimicrobial peptidegemcitabine resistanceintratumoral microbiotapancreatic ductal adenocarcinomaphotodynamic antibacterial therapy |
| spellingShingle | Renfa Liu Huanyu Yang Shuai Qu Peipei Yang Xin Zhi Yunxue Xu Zhifei Dai Linxue Qian Photodynamic eradication of intratumoral microbiota with bacteria‐targeted micelles overcomes gemcitabine resistance of pancreatic cancer Aggregate antimicrobial peptide gemcitabine resistance intratumoral microbiota pancreatic ductal adenocarcinoma photodynamic antibacterial therapy |
| title | Photodynamic eradication of intratumoral microbiota with bacteria‐targeted micelles overcomes gemcitabine resistance of pancreatic cancer |
| title_full | Photodynamic eradication of intratumoral microbiota with bacteria‐targeted micelles overcomes gemcitabine resistance of pancreatic cancer |
| title_fullStr | Photodynamic eradication of intratumoral microbiota with bacteria‐targeted micelles overcomes gemcitabine resistance of pancreatic cancer |
| title_full_unstemmed | Photodynamic eradication of intratumoral microbiota with bacteria‐targeted micelles overcomes gemcitabine resistance of pancreatic cancer |
| title_short | Photodynamic eradication of intratumoral microbiota with bacteria‐targeted micelles overcomes gemcitabine resistance of pancreatic cancer |
| title_sort | photodynamic eradication of intratumoral microbiota with bacteria targeted micelles overcomes gemcitabine resistance of pancreatic cancer |
| topic | antimicrobial peptide gemcitabine resistance intratumoral microbiota pancreatic ductal adenocarcinoma photodynamic antibacterial therapy |
| url | https://doi.org/10.1002/agt2.423 |
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