Functional and morphometric changes in children after neonatal arterial switch operation for transposition of the great arteries
Background : The increase in the survival of patients with D-Transposition of the great arteries (TGA) after arterial switch operation (ASO) has now turned our focus to the evaluation of mid and long-term outcomes. Although most patients are followed by conventional echocardiography, the study of ca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Annals of Pediatric Cardiology |
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| Online Access: | http://www.annalspc.com/article.asp?issn=0974-2069;year=2022;volume=15;issue=5;spage=447;epage=452;aulast=Walter |
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| author | Carin Cristina Walter Maria Clara Escobar-Diaz Sergi Cesar Bosco Alejandro Moscoso Garrido Joan Sanchez-de-Toledo |
| author_facet | Carin Cristina Walter Maria Clara Escobar-Diaz Sergi Cesar Bosco Alejandro Moscoso Garrido Joan Sanchez-de-Toledo |
| author_sort | Carin Cristina Walter |
| collection | DOAJ |
| description | Background : The increase in the survival of patients with D-Transposition of the great arteries (TGA) after arterial switch operation (ASO) has now turned our focus to the evaluation of mid and long-term outcomes. Although most patients are followed by conventional echocardiography, the study of cardiac functionality and morphometric parameters in children with TGA after ASO is scarce. The present study aims to describe the functional and morphometric echocardiographic changes in children after ASO.
Methods : We performed an observational study in patients aged 1–5 years with TGA who underwent neonatal ASO. Morphometric and functional echocardiographic parameters were analyzed in 21 patients and compared with 52 age-matched healthy controls.
Results : We found morphological and functional changes, especially in the right ventricle, which is more globular (right ventricle [RV] basal sphericity index 1.5 vs. 1.8, P = 0.016), and with a decreased systolic function compared to healthy controls (fractional area change 51 vs. 58%, P = 0.006; tricuspid annular plane systolic excursion 13 vs. 20 mm, P = 0.001; s' 7 vs. 12 cm/s, P = 0.001). In the speckle-tracking strain imaging, there was a decrease in the longitudinal deformation of the apical septal myocardium (-23% vs. -27%; P = 0.005). Preoperative systemic overload to the right ventricle could be an important factor in the origin of these changes.
Conclusions : In patients with TGA after ASO, there are morphometric and functional echocardiographic changes, such as globular form and decreased function, especially in the RV; the effect of these changes on long-term outcomes would require prospective follow-up studies. |
| first_indexed | 2024-03-13T10:40:08Z |
| format | Article |
| id | doaj.art-7d6436d353bc437b9647e5fc8d4bd09b |
| institution | Directory Open Access Journal |
| issn | 0974-2069 |
| language | English |
| last_indexed | 2024-03-13T10:40:08Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Pediatric Cardiology |
| spelling | doaj.art-7d6436d353bc437b9647e5fc8d4bd09b2023-05-18T04:57:13ZengWolters Kluwer Medknow PublicationsAnnals of Pediatric Cardiology0974-20692022-01-0115544745210.4103/apc.apc_46_22Functional and morphometric changes in children after neonatal arterial switch operation for transposition of the great arteriesCarin Cristina WalterMaria Clara Escobar-DiazSergi CesarBosco Alejandro Moscoso GarridoJoan Sanchez-de-ToledoBackground : The increase in the survival of patients with D-Transposition of the great arteries (TGA) after arterial switch operation (ASO) has now turned our focus to the evaluation of mid and long-term outcomes. Although most patients are followed by conventional echocardiography, the study of cardiac functionality and morphometric parameters in children with TGA after ASO is scarce. The present study aims to describe the functional and morphometric echocardiographic changes in children after ASO. Methods : We performed an observational study in patients aged 1–5 years with TGA who underwent neonatal ASO. Morphometric and functional echocardiographic parameters were analyzed in 21 patients and compared with 52 age-matched healthy controls. Results : We found morphological and functional changes, especially in the right ventricle, which is more globular (right ventricle [RV] basal sphericity index 1.5 vs. 1.8, P = 0.016), and with a decreased systolic function compared to healthy controls (fractional area change 51 vs. 58%, P = 0.006; tricuspid annular plane systolic excursion 13 vs. 20 mm, P = 0.001; s' 7 vs. 12 cm/s, P = 0.001). In the speckle-tracking strain imaging, there was a decrease in the longitudinal deformation of the apical septal myocardium (-23% vs. -27%; P = 0.005). Preoperative systemic overload to the right ventricle could be an important factor in the origin of these changes. Conclusions : In patients with TGA after ASO, there are morphometric and functional echocardiographic changes, such as globular form and decreased function, especially in the RV; the effect of these changes on long-term outcomes would require prospective follow-up studies.http://www.annalspc.com/article.asp?issn=0974-2069;year=2022;volume=15;issue=5;spage=447;epage=452;aulast=Walterarterial switch operationcardiac functionright ventricle functiontransposition of the great arteries |
| spellingShingle | Carin Cristina Walter Maria Clara Escobar-Diaz Sergi Cesar Bosco Alejandro Moscoso Garrido Joan Sanchez-de-Toledo Functional and morphometric changes in children after neonatal arterial switch operation for transposition of the great arteries Annals of Pediatric Cardiology arterial switch operation cardiac function right ventricle function transposition of the great arteries |
| title | Functional and morphometric changes in children after neonatal arterial switch operation for transposition of the great arteries |
| title_full | Functional and morphometric changes in children after neonatal arterial switch operation for transposition of the great arteries |
| title_fullStr | Functional and morphometric changes in children after neonatal arterial switch operation for transposition of the great arteries |
| title_full_unstemmed | Functional and morphometric changes in children after neonatal arterial switch operation for transposition of the great arteries |
| title_short | Functional and morphometric changes in children after neonatal arterial switch operation for transposition of the great arteries |
| title_sort | functional and morphometric changes in children after neonatal arterial switch operation for transposition of the great arteries |
| topic | arterial switch operation cardiac function right ventricle function transposition of the great arteries |
| url | http://www.annalspc.com/article.asp?issn=0974-2069;year=2022;volume=15;issue=5;spage=447;epage=452;aulast=Walter |
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