T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus

T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus

JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease in immunocompromised patients. Inherited and acquired T cell deficiencies are associated with PML. The incidence of PML is increasing with the introduction of new immunomodulatory agents...

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Bibliographic Details
Main Authors: Matthew D Lauver, Ge Jin, Katelyn N Ayers, Sarah N Carey, Charles S Specht, Catherine S Abendroth, Aron E Lukacher
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
polyomavirus
antibody escape
mouse
neurovirulence
T cell deficiency
Online Access:https://elifesciences.org/articles/83030

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