Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor

Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor

σS is a master transcription initiation factor that protects bacterial cells from various harmful environmental stresses including antibiotic pressure. Although its mechanism remains unclear, it is known that full activation of σS-mediated transcription requires a σS-specific activator, Crl. In this...

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Bibliographic Details
Main Authors: Juncao Xu, Kaijie Cui, Liqiang Shen, Jing Shi, Lingting Li, Linlin You, Chengli Fang, Guoping Zhao, Yu Feng, Bei Yang, Yu Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
transcription factors
RNA polymerase
Crl
transcription activation
sigma factor
stress response
Online Access:https://elifesciences.org/articles/50928

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