Notch1 Modulation of Cellular Calcium Regulates Mitochondrial Metabolism and Anti-Apoptotic Activity in T-Regulatory Cells

Notch1 Modulation of Cellular Calcium Regulates Mitochondrial Metabolism and Anti-Apoptotic Activity in T-Regulatory Cells

As the major hub of metabolic activity and an organelle sequestering pro-apoptogenic intermediates, mitochondria lie at the crossroads of cellular decisions of death and survival. Intracellular calcium is a key regulator of these outcomes with rapid, uncontrolled uptake into mitochondria, activating...

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Bibliographic Details
Main Authors: Neetu Saini, Sowmya Lakshminarayanan, Priyanka Kundu, Apurva Sarin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
NOTCH1
calcium
apoptosis
mitochondria
oxphos
Grp75
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.832159/full

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