Cytogenetic study of type 2 diabetes mellitus
Type 2 of diabetic mellitus (DM) is characterized by chronic hyperglycemia with abnormalities of fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. To understand cytogenetic changes associated with type 2 diabetic mellitus, cytogenetic analysis was done...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
College of Education for Pure Sciences
2022-01-01
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| Series: | Wasit Journal for Pure Sciences |
| Online Access: | https://wjps.uowasit.edu.iq/index.php/wjps/article/view/4 |
| _version_ | 1797288374766141440 |
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| author | Zafir Hassan Ghali Noor Jamal Hussein |
| author_facet | Zafir Hassan Ghali Noor Jamal Hussein |
| author_sort | Zafir Hassan Ghali |
| collection | DOAJ |
| description |
Type 2 of diabetic mellitus (DM) is characterized by chronic hyperglycemia with abnormalities of fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. To understand cytogenetic changes associated with type 2 diabetic mellitus, cytogenetic analysis was done on peripheral blood lymphocytes collected from twenty five type 2 DM patients using short term lymphocyte culture, and 15 apparently healthy people with as control group. The present study includes evaluation the cell cycle changes by determining blast and mitotic indices (BI and MI), as well as study the cellular kinetics by scoring replicative index (RI). The present data revealed significant depressions in BI [41.69±2.28] in patient's group compare with healthy group [54.46±4.56] and in MI [0.52±0.04] compare with healthy group [1.2±0.11] (P<0.01)]. The rate of cell cycle progression was also a reduction in diabetic patients [1.44± 0.10] in comparison with control [1.88± 0.01](P<0.05). We conclude that cytogenetic indices (BI, MI, and RI) are sensitive tools to achieve the cytogenetic abnormalities in type-2 diabetic mellitus
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| first_indexed | 2024-03-07T18:48:25Z |
| format | Article |
| id | doaj.art-7d6879e93eaa42caa01674b673ac6f0e |
| institution | Directory Open Access Journal |
| issn | 2790-5233 2790-5241 |
| language | English |
| last_indexed | 2024-03-07T18:48:25Z |
| publishDate | 2022-01-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | Wasit Journal for Pure Sciences |
| spelling | doaj.art-7d6879e93eaa42caa01674b673ac6f0e2024-03-02T02:03:47ZengCollege of Education for Pure SciencesWasit Journal for Pure Sciences2790-52332790-52412022-01-0110.31185/wjps.4Cytogenetic study of type 2 diabetes mellitusZafir Hassan Ghali 0Noor Jamal Hussein1Department of Biology, College of Education for pure science, Wasit University, IraqDepartment of Biology, College of Education for pure science, Wasit University, Iraq Type 2 of diabetic mellitus (DM) is characterized by chronic hyperglycemia with abnormalities of fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. To understand cytogenetic changes associated with type 2 diabetic mellitus, cytogenetic analysis was done on peripheral blood lymphocytes collected from twenty five type 2 DM patients using short term lymphocyte culture, and 15 apparently healthy people with as control group. The present study includes evaluation the cell cycle changes by determining blast and mitotic indices (BI and MI), as well as study the cellular kinetics by scoring replicative index (RI). The present data revealed significant depressions in BI [41.69±2.28] in patient's group compare with healthy group [54.46±4.56] and in MI [0.52±0.04] compare with healthy group [1.2±0.11] (P<0.01)]. The rate of cell cycle progression was also a reduction in diabetic patients [1.44± 0.10] in comparison with control [1.88± 0.01](P<0.05). We conclude that cytogenetic indices (BI, MI, and RI) are sensitive tools to achieve the cytogenetic abnormalities in type-2 diabetic mellitus https://wjps.uowasit.edu.iq/index.php/wjps/article/view/4 |
| spellingShingle | Zafir Hassan Ghali Noor Jamal Hussein Cytogenetic study of type 2 diabetes mellitus Wasit Journal for Pure Sciences |
| title | Cytogenetic study of type 2 diabetes mellitus |
| title_full | Cytogenetic study of type 2 diabetes mellitus |
| title_fullStr | Cytogenetic study of type 2 diabetes mellitus |
| title_full_unstemmed | Cytogenetic study of type 2 diabetes mellitus |
| title_short | Cytogenetic study of type 2 diabetes mellitus |
| title_sort | cytogenetic study of type 2 diabetes mellitus |
| url | https://wjps.uowasit.edu.iq/index.php/wjps/article/view/4 |
| work_keys_str_mv | AT zafirhassanghali cytogeneticstudyoftype2diabetesmellitus AT noorjamalhussein cytogeneticstudyoftype2diabetesmellitus |